Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: An animal study in rabbits

Rebecca Lensing*, André Bleich, Anna Smoczek, Silke Glage, Nina Ehlert, Tammo Luessenhop, Peter Behrens, Peter Paul Müller, Manfred Kietzmann, Martin Stieve

*Korrespondierende/r Autor/-in für diese Arbeit
20 Zitate (Scopus)

Abstract

Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.

OriginalspracheEnglisch
ZeitschriftActa Biomaterialia
Jahrgang9
Ausgabenummer1
Seiten (von - bis)4815-4825
Seitenumfang11
ISSN1742-7061
DOIs
PublikationsstatusVeröffentlicht - 01.01.2013

Fingerprint

Untersuchen Sie die Forschungsthemen von „Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: An animal study in rabbits“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren