Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Dirk Rades; Lukas J.A. Stalpers; Maarten C.C.M. Hulshof; Oliver Zschenker; Winfried Alberti; Caro C.E. Koning

doi:10.1016/j.radonc.2004.12.013

Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Dirk Rades^*, Lukas J.A. Stalpers, Maarten C.C.M. Hulshof, Oliver Zschenker, Winfried Alberti, Caro C.E. Koning

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Strahlentherapie

24 Zitate (Scopus)

Abstract

Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

Originalsprache	Englisch
Zeitschrift	Radiotherapy and Oncology
Jahrgang	75
Ausgabenummer	1
Seiten (von - bis)	70-73
Seitenumfang	4
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2004.12.013
Publikationsstatus	Veröffentlicht - 2005

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The authors would like to thank Mrs M. van der Kar for her assistance in logistics and organisation. This project was supported by the ESTRO (EDRO Technology Transfer Grant).

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10.1016/j.radonc.2004.12.013

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title = "Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression",

abstract = "Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27\%). Patients who regained walking ability were 20/78 (26\%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29\%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.",

author = "Dirk Rades and Stalpers, \{Lukas J.A.\} and Hulshof, \{Maarten C.C.M.\} and Oliver Zschenker and Winfried Alberti and Koning, \{Caro C.E.\}",

note = "Funding Information: The authors would like to thank Mrs M. van der Kar for her assistance in logistics and organisation. This project was supported by the ESTRO (EDRO Technology Transfer Grant). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2005",

doi = "10.1016/j.radonc.2004.12.013",

language = "English",

volume = "75",

pages = "70--73",

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T1 - Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

AU - Rades, Dirk

AU - Stalpers, Lukas J.A.

AU - Hulshof, Maarten C.C.M.

AU - Zschenker, Oliver

AU - Alberti, Winfried

AU - Koning, Caro C.E.

N1 - Funding Information: The authors would like to thank Mrs M. van der Kar for her assistance in logistics and organisation. This project was supported by the ESTRO (EDRO Technology Transfer Grant). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2005

Y1 - 2005

N2 - Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

AB - Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

UR - https://www.scopus.com/pages/publications/18144377397

U2 - 10.1016/j.radonc.2004.12.013

DO - 10.1016/j.radonc.2004.12.013

M3 - Journal articles

C2 - 15878103

AN - SCOPUS:18144377397

SN - 0167-8140

VL - 75

SP - 70

EP - 73

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 1

ER -

Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Abstract

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