Early gene expression of NK cell-activating chemokines in mice resistant to Leishmania major

Bettina Vester, Kerstin Müller, Werner Solbach, Tamás Laskay*

*Korrespondierende/r Autor/-in für diese Arbeit
61 Zitate (Scopus)

Abstract

Susceptibility of mice to Leishmania major is associated with an insufficient NK cell-mediated innate immune response. We analyzed the expression of NK cell-activating chemokines in vivo during the first days of infection in resistant and susceptible mice. The mRNA expression of gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and lymphotactin was upregulated 1 day after infection in the draining lymph nodes of resistant C57BL/6 mice but not in those of susceptible BALB/c mice. In vivo local treatment of BALB/c mice with recombinant IP-10 shortly after infection resulted in an enhanced NK cell activity in the draining lymph node. The data suggest that although the recruitment of NK cells is normal in susceptible mice, the lack of NK cell- activating chemokines is a factor resulting in a suboptimal NK cell-mediated defense.

OriginalspracheEnglisch
ZeitschriftInfection and Immunity
Jahrgang67
Ausgabenummer6
Seiten (von - bis)3155-3159
Seitenumfang5
ISSN0019-9567
PublikationsstatusVeröffentlicht - 01.06.1999

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

DFG-Fachsystematik

  • 204-05 Immunologie

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