Dydrogesterone: pharmacological profile and mechanism of action as luteal phase support in assisted reproduction

Georg Griesinger, Herman Tournaye, Nick Macklon, Felice Petraglia, Petra Arck, Christophe Blockeel, Peter van Amsterdam, Claire Pexman-Fieth, Bart Cjm Fauser


    The pharmacological and physiological profiles of progestogens used for luteal phase support during assisted reproductive technology are likely to be important in guiding clinical choice towards the most appropriate treatment option. Various micronized progesterone formulations with differing pharmacological profiles have been investigated for several purposes. Dydrogesterone, a stereoisomer of progesterone, is available in an oral form with high oral bioavailability; it has been used to treat a variety of conditions related to progesterone deficiency since the 1960s and has recently been approved for luteal phase support as part of an assisted reproductive technology treatment. The primary objective of this review is to critically analyse the clinical implications of the pharmacological and physiological properties of dydrogesterone for its uses in luteal phase support and in early pregnancy.

    ZeitschriftReproductive BioMedicine Online
    Seiten (von - bis)249-259
    PublikationsstatusVeröffentlicht - 02.2019

    Strategische Forschungsbereiche und Zentren

    • Zentren: Zentrum für Präimplantationsdiagnostik (PID)


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