Dissimilarity of airway and lung tissue microbiota in smokers undergoing surgery for lung cancer

Lena Reinhold*, Andreas Möllering, Sönke Wallis, Emanuel Palade, Kathrin Schäfer, Daniel Drömann, Jan Rupp, Simon Graspeuntner, Klaus Dalhoff

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity.

OriginalspracheEnglisch
Aufsatznummer794
ZeitschriftMicroorganisms
Jahrgang8
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - 06.2020

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Fingerprint

Untersuchen Sie die Forschungsthemen von „Dissimilarity of airway and lung tissue microbiota in smokers undergoing surgery for lung cancer“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren