Disease progression impacts health-related quality of life in amyotrophic lateral sclerosis

Tino Prell; Nayana Gaur; Beatrice Stubendorff; Annekathrin Rödiger; Otto W. Witte; Julian Grosskreutz

doi:10.1016/j.jns.2018.12.035

Disease progression impacts health-related quality of life in amyotrophic lateral sclerosis

Tino Prell^*, Nayana Gaur, Beatrice Stubendorff, Annekathrin Rödiger, Otto W. Witte, Julian Grosskreutz

^*Korrespondierende/r Autor/-in für diese Arbeit

Friedrich-Schiller-Universität Jena

25 Zitate (Scopus)

Abstract

Objectives: To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). Methods: A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. Results: ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76% of the ALSAQ-40 summary index variance. Progression rate alone explained 7% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. Conclusion: Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.

Originalsprache	Englisch
Zeitschrift	Journal of the Neurological Sciences
Jahrgang	397
Seiten (von - bis)	92-95
Seitenumfang	4
ISSN	0022-510X
DOIs	https://doi.org/10.1016/j.jns.2018.12.035
Publikationsstatus	Veröffentlicht - 15.02.2019
Extern publiziert	Ja

Fördermittel

The present study was supported by the German Bundesministerium für Bildung und Forschung (BMBF) grant OnWEBDuals (FKZ 01ED015511A) to Julian Grosskreutz under the aegis of the EU Joint Programme - Neurodegenerative Disease Research (JPND) and a BMBF grant PYRAMID (FKZ 01GM1304) to Julian Grosskreutz in the framework of the ERANET E-RARE program. The present study was supported by the German Bundesministerium für Bildung und Forschung (BMBF) grant OnWEBDuals ( FKZ 01ED015511A ) to Julian Grosskreutz under the aegis of the EU Joint Programme - Neurodegenerative Disease Research (JPND) and a BMBF grant PYRAMID ( FKZ 01GM1304 ) to Julian Grosskreutz in the framework of the ERANET E-RARE program.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Zentren: Neuromuskuläres Zentrum Schleswig-Holstein

Dokumente

10.1016/j.jns.2018.12.035

Weitere Links

Link to publication in Scopus

Zitieren

@article{73e09ff298954bf68d4ab6dbc6303780,

title = "Disease progression impacts health-related quality of life in amyotrophic lateral sclerosis",

abstract = "Objectives: To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). Methods: A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. Results: ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76\% of the ALSAQ-40 summary index variance. Progression rate alone explained 7\% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. Conclusion: Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.",

author = "Tino Prell and Nayana Gaur and Beatrice Stubendorff and Annekathrin R{\"o}diger and Witte, \{Otto W.\} and Julian Grosskreutz",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2019",

month = feb,

day = "15",

doi = "10.1016/j.jns.2018.12.035",

language = "English",

volume = "397",

pages = "92--95",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Disease progression impacts health-related quality of life in amyotrophic lateral sclerosis

AU - Prell, Tino

AU - Gaur, Nayana

AU - Stubendorff, Beatrice

AU - Rödiger, Annekathrin

AU - Witte, Otto W.

AU - Grosskreutz, Julian

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Objectives: To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). Methods: A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. Results: ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76% of the ALSAQ-40 summary index variance. Progression rate alone explained 7% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. Conclusion: Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.

AB - Objectives: To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). Methods: A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. Results: ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76% of the ALSAQ-40 summary index variance. Progression rate alone explained 7% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. Conclusion: Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.

UR - https://www.scopus.com/pages/publications/85059160133

U2 - 10.1016/j.jns.2018.12.035

DO - 10.1016/j.jns.2018.12.035

M3 - Journal articles

C2 - 30597420

AN - SCOPUS:85059160133

SN - 0022-510X

VL - 397

SP - 92

EP - 95

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

ER -