Discrepant target detection and action monitoring in obsessive-compulsive disorder

Sönke Johannes*, Bernardina M. Wieringa, Wido Nager, Dominik Rada, Reinhard Dengler, Hinderk M. Emrich, Thomas F. Münte, Detlef E. Dietrich

*Korrespondierende/r Autor/-in für diese Arbeit
138 Zitate (Scopus)

Abstract

Obsessive-compulsive disorder (OCD) has been related to altered mechanisms of action monitoring and target detection, and it has been hypothesized that hyperactive striatal-cortical circuits constitute the underlying pathophysiology. This study used event-related brain potentials (ERPs) to explore this hypothesis. A choice reaction time experiment was carried out in a group of OCD patients and a normal comparison group. The P3b component of the ERP to targets was taken as an indicator of the target-evaluation process and the response-locked error-related negativity (ERN) served as an indicator of action monitoring. We hypothesized that the OCD group would show a shortened P3b latency and an amplitude-enhanced ERN. Consistent with our expectations, the P3b latency was shorter and the ERN amplitude was higher in the OCD group. Unexpectedly, we also observed a prolonged ERN latency in the OCD group and a more posterior topography of this component. The data provide partial support for the hypothesis of a hyperactive neural network in OCD. In addition the disorder must involve pathophysiological processes that are presumably related to other aspects of its complex and heterogeneous clinical hallmarks.

OriginalspracheEnglisch
ZeitschriftPsychiatry Research - Neuroimaging
Jahrgang108
Ausgabenummer2
Seiten (von - bis)101-110
Seitenumfang10
ISSN0925-4927
DOIs
PublikationsstatusVeröffentlicht - 30.11.2001

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Fingerprint

Untersuchen Sie die Forschungsthemen von „Discrepant target detection and action monitoring in obsessive-compulsive disorder“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren