Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology

The discrimination of tumor-infiltrated tissue from non-tumorous brain tissue
during neurosurgical tumor excision is a major challenge in neurosurgery. It is
critical to achieve full tumor removal since it directly correlates with the survival
rate of the patient. Optical coherence tomography (OCT) might be an
additional imaging method in the field of neurosurgery that enables the
classification of different levels of tumor infiltration and non-tumorous tissue.
This work investigated two OCT systems with different imaging wavelengths
(930 nm/1310 nm) and different resolutions (axial (air): 4.9 mm/16 mm, lateral:
5.2 mm/22 mm) in their ability to identify different levels of tumor infiltration
based on freshly excised ex vivo brain samples. A convolutional neural network
was used for the classification. For both systems, the neural network could
achieve classification accuracies above 91% for discriminating between healthy
white matter and highly tumor infiltrated white matter (tumor infiltration >60%)
.This work shows that both OCT systems with different optical properties
achieve similar results regarding the identification of different stages of brain
tumor infiltration.