TY - JOUR
T1 - Differential fatty acid analysis of cerebrospinal fluid in infants and young children with suspected meningitis
AU - Ekhtiyari, Elham
AU - Barzegar, Mohammad
AU - Mehdizadeh, Amir
AU - Shaaker, Maghsood
AU - Ghodoosifar, Sepideh
AU - Abhari, Alireza
AU - Darabi, Masoud
N1 - Funding Information:
We are grateful to all of the subjects who kindly agreed to participate in this study. The authors would like to thank Maryam Darabi, PhD (Institute of Clinical Chemistry, Zurich), for her critical reading of the manuscript. This study was partially conducted as part of a Master’s thesis project no. 94/1-2/2 at the Tabriz University of Medical Sciences for the first author. This work was supported by the Pediatric Health Research Center at the Tabriz University of Medical Sciences [grant number 5/93/140]. Support was also provided by the Emergency Medicine Research Team at Tabriz University of Medical Sciences.
Funding Information:
This study was partially conducted as part of a Master’s thesis project no. 94/1-2/2 at the Tabriz University of Medical Sciences for the first author. This work was supported by the Pediatric Health Research Center at the Tabriz University of Medical Sciences [grant number 5/93/140]. Support was also provided by the Emergency Medicine Research Team at Tabriz University of Medical Sciences.
Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Purpose: Meningitis is relatively common in infants and young children and can cause permanent brain damage. The aim of this study was to determine whether meningitis is associated with fatty acids in cerebrospinal fluid (CSF). Methods: CSF samples from children between 3 months and 6 years of age admitted to the Tabriz public hospitals who met clinical criteria of meningitis were collected at enrollment. A total of 81 samples were analyzed for fatty acid profile by gas–liquid chromatography. Results: Children with a purulent meningitis demonstrated a higher percentage of oleic acid (p < 0.05, >10 %) and lower percentages of omega-3 polyunsaturated fatty acids (p < 0.001, <−40 %) than aseptic meningitis and nonmeningitis groups did. There was an inverse relationship between CSF long-chain omega-3 fatty acids and the total number of leukocytes and differential counts of neutrophils and lymphocytes in the purulent meningitis group. Moreover, significantly lower omega-3 fatty acids (p = 0.001, −37 %) and higher ratio of n-6/n-3 (p = 0.02, −29 %) were found in patients with purulent meningitis with sepsis than in those with meningitis and no sepsis. Conclusions: This study provides evidence that purulent meningitis and its complication with sepsis are associated with important disturbances in CSF fatty acids, mainly deficiency in long-chain omega-3 polyunsaturated fatty acids.
AB - Purpose: Meningitis is relatively common in infants and young children and can cause permanent brain damage. The aim of this study was to determine whether meningitis is associated with fatty acids in cerebrospinal fluid (CSF). Methods: CSF samples from children between 3 months and 6 years of age admitted to the Tabriz public hospitals who met clinical criteria of meningitis were collected at enrollment. A total of 81 samples were analyzed for fatty acid profile by gas–liquid chromatography. Results: Children with a purulent meningitis demonstrated a higher percentage of oleic acid (p < 0.05, >10 %) and lower percentages of omega-3 polyunsaturated fatty acids (p < 0.001, <−40 %) than aseptic meningitis and nonmeningitis groups did. There was an inverse relationship between CSF long-chain omega-3 fatty acids and the total number of leukocytes and differential counts of neutrophils and lymphocytes in the purulent meningitis group. Moreover, significantly lower omega-3 fatty acids (p = 0.001, −37 %) and higher ratio of n-6/n-3 (p = 0.02, −29 %) were found in patients with purulent meningitis with sepsis than in those with meningitis and no sepsis. Conclusions: This study provides evidence that purulent meningitis and its complication with sepsis are associated with important disturbances in CSF fatty acids, mainly deficiency in long-chain omega-3 polyunsaturated fatty acids.
UR - http://www.scopus.com/inward/record.url?scp=84991045052&partnerID=8YFLogxK
U2 - 10.1007/s00381-016-3232-x
DO - 10.1007/s00381-016-3232-x
M3 - Journal articles
C2 - 27596000
AN - SCOPUS:84991045052
SN - 0256-7040
VL - 33
SP - 111
EP - 117
JO - Child's Nervous System
JF - Child's Nervous System
IS - 1
ER -
