Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

Peter Lamprecht; Hilke Bruhl; Anika Erdmann; Konstanze Holl-Ulrich; Elena Csernok; Ulrike Seitzer; Matthias Mack; Alfred C. Feller; Eva Reinhold-Keller; Wolfgang L. Gross; Antje Muller

doi:10.1016/S1521-6616(03)00121-9

Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

Peter Lamprecht^*, Hilke Bruhl, Anika Erdmann, Konstanze Holl-Ulrich, Elena Csernok, Ulrike Seitzer, Matthias Mack, Alfred C. Feller, Eva Reinhold-Keller, Wolfgang L. Gross, Antje Muller

^*Korrespondierende/r Autor/-in für diese Arbeit

58 Zitate (Scopus)

Abstract

Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4⁺CD28^- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4⁺CD28^- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4⁺CD28^- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4⁺CD28^- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4⁺CD28^-CCR5⁺ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.

Originalsprache	Englisch
Zeitschrift	Clinical Immunology
Jahrgang	108
Ausgabenummer	1
Seiten (von - bis)	1-7
Seitenumfang	7
ISSN	1521-6616
DOIs	https://doi.org/10.1016/S1521-6616(03)00121-9
Publikationsstatus	Veröffentlicht - 01.07.2003

Fördermittel

Supported by Grants SFB367/C1 (U.S.) and SFB 367/A8 (P.L., A.M., and W.L.G.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), and Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M. and P.L.). We thank Kirsten Barre, Linda Carstens, Isabell Wenzel, and Gabriele Feldhoff for excellent technical assistance. We are grateful to the patients for their cooperation.

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SDG 3 – Gesundheit und Wohlergehen

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1016/S1521-6616(03)00121-9

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Lamprecht, P., Bruhl, H., Erdmann, A., Holl-Ulrich, K., Csernok, E., Seitzer, U., Mack, M., Feller, A. C., Reinhold-Keller, E., Gross, W. L., & Muller, A. (2003). Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clinical Immunology, 108(1), 1-7. https://doi.org/10.1016/S1521-6616(03)00121-9

@article{076bab21021249f8b04724bf883762f9,

title = "Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis",

abstract = "Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28-CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.",

author = "Peter Lamprecht and Hilke Bruhl and Anika Erdmann and Konstanze Holl-Ulrich and Elena Csernok and Ulrike Seitzer and Matthias Mack and Feller, \{Alfred C.\} and Eva Reinhold-Keller and Gross, \{Wolfgang L.\} and Antje Muller",

note = "Funding Information: Supported by Grants SFB367/C1 (U.S.) and SFB 367/A8 (P.L., A.M., and W.L.G.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), and Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M. and P.L.). We thank Kirsten Barre, Linda Carstens, Isabell Wenzel, and Gabriele Feldhoff for excellent technical assistance. We are grateful to the patients for their cooperation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2003",

month = jul,

day = "1",

doi = "10.1016/S1521-6616(03)00121-9",

language = "English",

volume = "108",

pages = "1--7",

journal = "Clinical Immunology",

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Lamprecht, P, Bruhl, H, Erdmann, A, Holl-Ulrich, K, Csernok, E, Seitzer, U, Mack, M, Feller, AC, Reinhold-Keller, E, Gross, WL & Muller, A 2003, 'Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis', Clinical Immunology, Jg. 108, Nr. 1, S. 1-7. https://doi.org/10.1016/S1521-6616(03)00121-9

Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. / Lamprecht, Peter; Bruhl, Hilke; Erdmann, Anika et al.
in: Clinical Immunology, Jahrgang 108, Nr. 1, 01.07.2003, S. 1-7.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

AU - Lamprecht, Peter

AU - Bruhl, Hilke

AU - Erdmann, Anika

AU - Holl-Ulrich, Konstanze

AU - Csernok, Elena

AU - Seitzer, Ulrike

AU - Mack, Matthias

AU - Feller, Alfred C.

AU - Reinhold-Keller, Eva

AU - Gross, Wolfgang L.

AU - Muller, Antje

N1 - Funding Information: Supported by Grants SFB367/C1 (U.S.) and SFB 367/A8 (P.L., A.M., and W.L.G.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), and Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M. and P.L.). We thank Kirsten Barre, Linda Carstens, Isabell Wenzel, and Gabriele Feldhoff for excellent technical assistance. We are grateful to the patients for their cooperation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28-CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.

AB - Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28-CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.

UR - https://www.scopus.com/pages/publications/0037675815

U2 - 10.1016/S1521-6616(03)00121-9

DO - 10.1016/S1521-6616(03)00121-9

M3 - Journal articles

C2 - 12865065

AN - SCOPUS:0037675815

SN - 1521-6616

VL - 108

SP - 1

EP - 7

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -