Determination of the brain-blood partition coefficient for water in mice using MRI

Christoph Leithner; Susanne Müller; Martina Füchtemeier; Ute Lindauer; Ulrich Dirnagl; Georg Royl

doi:10.1038/jcbfm.2010.160

Determination of the brain-blood partition coefficient for water in mice using MRI

Christoph Leithner^*, Susanne Müller, Martina Füchtemeier, Ute Lindauer, Ulrich Dirnagl, Georg Royl

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Neurologie

15 Zitate (Scopus)

Abstract

Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.

Originalsprache	Englisch
Zeitschrift	Journal of Cerebral Blood Flow and Metabolism
Jahrgang	30
Ausgabenummer	11
Seiten (von - bis)	1821-1824
Seitenumfang	4
ISSN	0271-678X
DOIs	https://doi.org/10.1038/jcbfm.2010.160
Publikationsstatus	Veröffentlicht - 01.11.2010

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abstract = "Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.",

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AU - Müller, Susanne

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AU - Lindauer, Ute

AU - Dirnagl, Ulrich

AU - Royl, Georg

PY - 2010/11/1

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N2 - Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.

AB - Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.

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Determination of the brain-blood partition coefficient for water in mice using MRI

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