Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function

Vasily Matkivsky*, Alexander Moiseev, Pavel Shilyagin, Alexander Rodionov, Hendrik Spahr, Clara Pfäffle, Gereon Hüttmann, Dierck Hillmann, Grigory Gelikonov

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

A method for numerical estimation and correction of aberrations of the eye in fundus imaging with optical coherence tomography (OCT) is presented. Aberrations are determined statistically by using the estimate based on likelihood function maximization. The method can be considered as an extension of the phase gradient autofocusing algorithm in synthetic aperture radar imaging to 2D optical aberration correction. The efficacy of the proposed method has been demonstrated in OCT fundus imaging with 6λ aberrations. After correction, single photoreceptors were resolved. It is also shown that wave front distortions with high spatial frequencies can be determined and corrected.

OriginalspracheEnglisch
Aufsatznummere202000112
ZeitschriftJournal of Biophotonics
Jahrgang13
Ausgabenummer10
ISSN1864-063X
DOIs
PublikationsstatusVeröffentlicht - 01.10.2020

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Biomedizintechnik

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