Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions

EPIPARK Study Group

doi:10.1038/s41531-023-00551-8

Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions

EPIPARK Study Group

Segeberger Kliniken

Abstract

Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive symptoms in PD patients and disease controls (DC). PD patients reported depressive symptoms at similar frequencies as DC but were on antidepressants, especially Mirtazapine, more frequently. Still, in both groups, a high proportion of patients with clinically significant depressive symptoms was not receiving medication. Diagnosis and treatment of depressive symptoms both in PD and DC should be improved.

Originalsprache	Englisch
Aufsatznummer	113
Zeitschrift	NPJ Parkinson's disease
Jahrgang	9
Ausgabenummer	1
ISSN	2373-8057
DOIs	https://doi.org/10.1038/s41531-023-00551-8
Publikationsstatus	Veröffentlicht - 12.2023

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

206-07 Klinische Neurologie; Neurochirurgie und Neuroradiologie
206-08 Kognitive und Systemische Humanneurowissenschaften
206-10 Klinische Psychiatrie, Psychotherapie und Kinder- und Jugendpsychiatrie

UN SDGs

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10.1038/s41531-023-00551-8

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abstract = "Depressive symptoms in Parkinson{\textquoteright}s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive symptoms in PD patients and disease controls (DC). PD patients reported depressive symptoms at similar frequencies as DC but were on antidepressants, especially Mirtazapine, more frequently. Still, in both groups, a high proportion of patients with clinically significant depressive symptoms was not receiving medication. Diagnosis and treatment of depressive symptoms both in PD and DC should be improved.",

author = "{EPIPARK Study Group} and Tatiana Usnich and Bj{\"o}rn Hauptmann and Henrike Hanssen and Jannik Prasuhn and Alexander Balck and Max Borsche and Vera Tadic and Annika Klee and Greta Noblejas-Sanchez and Vollstedt, {Eva Juliane} and Christine Klein and Norbert Br{\"u}ggemann and Meike Kasten and Julia Graf and Nathalie Schell and Raluca Modreanu and Barbara Staemmler and Elena Loewin",

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AU - EPIPARK Study Group

AU - Usnich, Tatiana

AU - Hauptmann, Björn

AU - Hanssen, Henrike

AU - Prasuhn, Jannik

AU - Balck, Alexander

AU - Borsche, Max

AU - Tadic, Vera

AU - Klee, Annika

AU - Noblejas-Sanchez, Greta

AU - Vollstedt, Eva Juliane

AU - Klein, Christine

AU - Brüggemann, Norbert

AU - Kasten, Meike

AU - Graf, Julia

AU - Schell, Nathalie

AU - Modreanu, Raluca

AU - Staemmler, Barbara

AU - Loewin, Elena

PY - 2023/12

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N2 - Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive symptoms in PD patients and disease controls (DC). PD patients reported depressive symptoms at similar frequencies as DC but were on antidepressants, especially Mirtazapine, more frequently. Still, in both groups, a high proportion of patients with clinically significant depressive symptoms was not receiving medication. Diagnosis and treatment of depressive symptoms both in PD and DC should be improved.

AB - Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive symptoms in PD patients and disease controls (DC). PD patients reported depressive symptoms at similar frequencies as DC but were on antidepressants, especially Mirtazapine, more frequently. Still, in both groups, a high proportion of patients with clinically significant depressive symptoms was not receiving medication. Diagnosis and treatment of depressive symptoms both in PD and DC should be improved.

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ER -

Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions

Abstract

Strategische Forschungsbereiche und Zentren

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UN SDGs

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