Cytokine release of human NK cells solely triggered with Poly I: C

Sandra Wulff, Ralph Pries, Barbara Wollenberg*

*Korrespondierende/r Autor/-in für diese Arbeit
10 Zitate (Scopus)

Abstract

Natural killer (NK) cells play a crucial role in innate immunity as effectors against tumor cells and pathogen-infected cells. Our data show for the first time that NK cells produce high levels of cytokines interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells. An incubation period of 48. h is necessary to induce cytokine release by Poly I:C. These data suggest Poly I:C as a competent direct activator and immunomodulator of NK cell functions.

OriginalspracheEnglisch
ZeitschriftCellular Immunology
Jahrgang263
Ausgabenummer2
Seiten (von - bis)135-137
Seitenumfang3
ISSN0008-8749
DOIs
PublikationsstatusVeröffentlicht - 16.06.2010

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