TY - JOUR
T1 - Culprit vessel-related myocardial mechanics and prognostic implications following acute myocardial infarction
AU - Backhaus, Sören J.
AU - Kowallick, Johannes T.
AU - Stiermaier, Thomas
AU - Lange, Torben
AU - Koschalka, Alexander
AU - Navarra, Jenny Lou
AU - Lotz, Joachim
AU - Kutty, Shelby
AU - Bigalke, Boris
AU - Gutberlet, Matthias
AU - Feistritzer, Hans Josef
AU - Hasenfuß, Gerd
AU - Thiele, Holger
AU - Schuster, Andreas
AU - Eitel, Ingo
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - BACKGROUND: Prognosis in acute myocardial infarction (AMI) depends on the amount of infarct-related artery (IRA)-subtended myocardium and associated damage but has not been described in great detail. Consequently, we sought to describe IRA-associated pathophysiological consequences using cardiac magnetic resonance (CMR).METHODS: 1235 AMI patients (n = 795 ST-elevation (STEMI) and 440 non-STEMI) underwent CMR following percutaneous coronary intervention. Blinded core-laboratory data were compared according to left anterior descending (LAD), left circumflex (LCx) and right coronary artery (RCA) regarding major adverse clinical events (MACE) within 12 months. Left ventricular (LV) global longitudinal/circumferential/radial (GLS/GCS/GRS) as well as left atrial (LA) total (ε
s), passive (ε
e) and active (ε
a) strains were determined using CMR-feature tracking. Tissue characterisation included infarct size (IS) and microvascular obstruction.
RESULTS: LAD and LCx were associated with higher mortality compared to RCA lesions (4.6% and 4.4% vs 1.6%). LAD lesions showed largest IS (16.8%), largest ventricular [LV ejection fraction (EF) 47.4%, GLS - 13.2%, GCS - 20.8%] and atrial (ε
s 20.2%) impairment. There was less impairment in LCx (IS 11.8%, LVEF 50.8%, GLS - 17.4%, GCS - 25.0%, ε
s 20.7%) followed by RCA lesions (IS 11.3%, LVEF 50.8%, GLS - 19.1%, GCS - 26.6%, ε
s 21.7%). In AUC analyses, ε
s (LAD, RCA) and GLS (LCx) best predicted MACE (AUC > 0.69). Multivariate analyses identified ε
s (p = 0.017) in LAD and GLS (p = 0.034) in LCx infarcts as independent predictors of MACE.
CONCLUSIONS: CMR allows IRA-specific phenotyping and characterisation of morphologic and functional changes. These alterations carry infarct-specific prognostic implications, and may represent novel diagnostic and therapeutic targets following AMI.TRIAL REGISTRATION: ClinicalTrials.gov: NCT00712101 and NCT01612312.
AB - BACKGROUND: Prognosis in acute myocardial infarction (AMI) depends on the amount of infarct-related artery (IRA)-subtended myocardium and associated damage but has not been described in great detail. Consequently, we sought to describe IRA-associated pathophysiological consequences using cardiac magnetic resonance (CMR).METHODS: 1235 AMI patients (n = 795 ST-elevation (STEMI) and 440 non-STEMI) underwent CMR following percutaneous coronary intervention. Blinded core-laboratory data were compared according to left anterior descending (LAD), left circumflex (LCx) and right coronary artery (RCA) regarding major adverse clinical events (MACE) within 12 months. Left ventricular (LV) global longitudinal/circumferential/radial (GLS/GCS/GRS) as well as left atrial (LA) total (ε
s), passive (ε
e) and active (ε
a) strains were determined using CMR-feature tracking. Tissue characterisation included infarct size (IS) and microvascular obstruction.
RESULTS: LAD and LCx were associated with higher mortality compared to RCA lesions (4.6% and 4.4% vs 1.6%). LAD lesions showed largest IS (16.8%), largest ventricular [LV ejection fraction (EF) 47.4%, GLS - 13.2%, GCS - 20.8%] and atrial (ε
s 20.2%) impairment. There was less impairment in LCx (IS 11.8%, LVEF 50.8%, GLS - 17.4%, GCS - 25.0%, ε
s 20.7%) followed by RCA lesions (IS 11.3%, LVEF 50.8%, GLS - 19.1%, GCS - 26.6%, ε
s 21.7%). In AUC analyses, ε
s (LAD, RCA) and GLS (LCx) best predicted MACE (AUC > 0.69). Multivariate analyses identified ε
s (p = 0.017) in LAD and GLS (p = 0.034) in LCx infarcts as independent predictors of MACE.
CONCLUSIONS: CMR allows IRA-specific phenotyping and characterisation of morphologic and functional changes. These alterations carry infarct-specific prognostic implications, and may represent novel diagnostic and therapeutic targets following AMI.TRIAL REGISTRATION: ClinicalTrials.gov: NCT00712101 and NCT01612312.
UR - http://www.scopus.com/inward/record.url?scp=85068862074&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/820b901b-e3a1-3aec-906c-0f5f7f4a5556/
U2 - 10.1007/s00392-019-01514-x
DO - 10.1007/s00392-019-01514-x
M3 - Journal articles
C2 - 31278521
AN - SCOPUS:85068862074
SN - 1861-0684
VL - 109
SP - 339
EP - 349
JO - Clinical Research in Cardiology
JF - Clinical Research in Cardiology
IS - 3
ER -