CSA: Comprehensive comparison of pairwise protein structure alignments

Inken Wohlers; Noël Malod-Dognin; Rumen Andonov; Gunnar W. Klau

doi:10.1093/nar/gks362

CSA: Comprehensive comparison of pairwise protein structure alignments

Inken Wohlers^*, Noël Malod-Dognin, Rumen Andonov, Gunnar W. Klau

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Neurologie

12 Zitate (Scopus)

Abstract

CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

Originalsprache	Englisch
Zeitschrift	Nucleic Acids Research
Jahrgang	40
Ausgabenummer	W1
Seiten (von - bis)	W303-W309
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gks362
Publikationsstatus	Veröffentlicht - 07.2012

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10.1093/nar/gks362

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title = "CSA: Comprehensive comparison of pairwise protein structure alignments",

abstract = "CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.",

author = "Inken Wohlers and No{\"e}l Malod-Dognin and Rumen Andonov and Klau, {Gunnar W.}",

note = "Funding Information: Deutsche Forschungsgemeinschaft [KL 1390/2-1, in part]. Funding for open access charge: INRIA Sophia Antipolis – M{\'e}diterran{\'e}e.",

year = "2012",

month = jul,

doi = "10.1093/nar/gks362",

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AU - Wohlers, Inken

AU - Malod-Dognin, Noël

AU - Andonov, Rumen

AU - Klau, Gunnar W.

N1 - Funding Information: Deutsche Forschungsgemeinschaft [KL 1390/2-1, in part]. Funding for open access charge: INRIA Sophia Antipolis – Méditerranée.

PY - 2012/7

Y1 - 2012/7

N2 - CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

AB - CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

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DO - 10.1093/nar/gks362

M3 - Journal articles

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AN - SCOPUS:84864493874

SN - 0305-1048

VL - 40

SP - W303-W309

JO - Nucleic Acids Research

JF - Nucleic Acids Research

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CSA: Comprehensive comparison of pairwise protein structure alignments

Abstract

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