Crystallization of proteins under microgravity

Volker A. Erdmann; Corinna Lippmann; Christian Betzel; Zbyszek Dauter; Keith Wilson; Rolf Hilgenfeld; Julia Hoven; Alexander Liesum; Wolfram Saenger; Anke Müller-Fahrnow; Winfried Hinrichs; Martina Düvel; Georg E. Schulz; Christoph W. Müller; Heinz G. Wittmann; Ada Yonath; Gabriela Weber; Karin Stegen; Andreas Plaas-Link

doi:10.1016/0014-5793(89)81526-1

Crystallization of proteins under microgravity

Volker A. Erdmann^*, Corinna Lippmann, Christian Betzel, Zbyszek Dauter, Keith Wilson, Rolf Hilgenfeld, Julia Hoven, Alexander Liesum, Wolfram Saenger, Anke Müller-Fahrnow, Winfried Hinrichs, Martina Düvel, Georg E. Schulz, Christoph W. Müller, Heinz G. Wittmann, Ada Yonath, Gabriela Weber, Karin Stegen, Andreas Plaas-Link

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biochemie

35 Zitate (Scopus)

Abstract

For the crystallization of proteins under microgravity conditions, a Chinese re-entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity conditions crystal growth can only be expected under those crystallization conditions which also permit crystal growthon earth. A number of space-grown crystals were larger in size and of a better quality in their ability to diffract X-rays than the corresponding ground control crystals grown at the Chinese launch site. However, the space-grown crystals have not reached the X-ray diffraction quality of the crystals obtained under optimal conditions in the home laboratories.

Originalsprache	Englisch
Zeitschrift	FEBS Letters
Jahrgang	259
Ausgabenummer	1
Seiten (von - bis)	194-198
Seitenumfang	5
ISSN	0014-5793
DOIs	https://doi.org/10.1016/0014-5793(89)81526-1
Publikationsstatus	Veröffentlicht - 18.12.1989

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Erdmann, V. A., Lippmann, C., Betzel, C., Dauter, Z., Wilson, K., Hilgenfeld, R., Hoven, J., Liesum, A., Saenger, W., Müller-Fahrnow, A., Hinrichs, W., Düvel, M., Schulz, G. E., Müller, C. W., Wittmann, H. G., Yonath, A., Weber, G., Stegen, K., & Plaas-Link, A. (1989). Crystallization of proteins under microgravity. FEBS Letters, 259(1), 194-198. https://doi.org/10.1016/0014-5793(89)81526-1

@article{fc417b5e1c3147ad828455124d50c672,

title = "Crystallization of proteins under microgravity",

abstract = "For the crystallization of proteins under microgravity conditions, a Chinese re-entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity conditions crystal growth can only be expected under those crystallization conditions which also permit crystal growthon earth. A number of space-grown crystals were larger in size and of a better quality in their ability to diffract X-rays than the corresponding ground control crystals grown at the Chinese launch site. However, the space-grown crystals have not reached the X-ray diffraction quality of the crystals obtained under optimal conditions in the home laboratories.",

author = "Erdmann, \{Volker A.\} and Corinna Lippmann and Christian Betzel and Zbyszek Dauter and Keith Wilson and Rolf Hilgenfeld and Julia Hoven and Alexander Liesum and Wolfram Saenger and Anke M{\"u}ller-Fahrnow and Winfried Hinrichs and Martina D{\"u}vel and Schulz, \{Georg E.\} and M{\"u}ller, \{Christoph W.\} and Wittmann, \{Heinz G.\} and Ada Yonath and Gabriela Weber and Karin Stegen and Andreas Plaas-Link",

year = "1989",

month = dec,

day = "18",

doi = "10.1016/0014-5793(89)81526-1",

language = "English",

volume = "259",

pages = "194--198",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc",

number = "1",

}

Erdmann, VA, Lippmann, C, Betzel, C, Dauter, Z, Wilson, K, Hilgenfeld, R, Hoven, J, Liesum, A, Saenger, W, Müller-Fahrnow, A, Hinrichs, W, Düvel, M, Schulz, GE, Müller, CW, Wittmann, HG, Yonath, A, Weber, G, Stegen, K & Plaas-Link, A 1989, 'Crystallization of proteins under microgravity', FEBS Letters, Jg. 259, Nr. 1, S. 194-198. https://doi.org/10.1016/0014-5793(89)81526-1

TY - JOUR

T1 - Crystallization of proteins under microgravity

AU - Erdmann, Volker A.

AU - Lippmann, Corinna

AU - Betzel, Christian

AU - Dauter, Zbyszek

AU - Wilson, Keith

AU - Hilgenfeld, Rolf

AU - Hoven, Julia

AU - Liesum, Alexander

AU - Saenger, Wolfram

AU - Müller-Fahrnow, Anke

AU - Hinrichs, Winfried

AU - Düvel, Martina

AU - Schulz, Georg E.

AU - Müller, Christoph W.

AU - Wittmann, Heinz G.

AU - Yonath, Ada

AU - Weber, Gabriela

AU - Stegen, Karin

AU - Plaas-Link, Andreas

PY - 1989/12/18

Y1 - 1989/12/18

N2 - For the crystallization of proteins under microgravity conditions, a Chinese re-entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity conditions crystal growth can only be expected under those crystallization conditions which also permit crystal growthon earth. A number of space-grown crystals were larger in size and of a better quality in their ability to diffract X-rays than the corresponding ground control crystals grown at the Chinese launch site. However, the space-grown crystals have not reached the X-ray diffraction quality of the crystals obtained under optimal conditions in the home laboratories.

AB - For the crystallization of proteins under microgravity conditions, a Chinese re-entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity conditions crystal growth can only be expected under those crystallization conditions which also permit crystal growthon earth. A number of space-grown crystals were larger in size and of a better quality in their ability to diffract X-rays than the corresponding ground control crystals grown at the Chinese launch site. However, the space-grown crystals have not reached the X-ray diffraction quality of the crystals obtained under optimal conditions in the home laboratories.

UR - https://www.scopus.com/pages/publications/0024834966

U2 - 10.1016/0014-5793(89)81526-1

DO - 10.1016/0014-5793(89)81526-1

M3 - Journal articles

AN - SCOPUS:0024834966

SN - 0014-5793

VL - 259

SP - 194

EP - 198

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Crystallization of proteins under microgravity

Abstract

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