Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression

Sonja Von Aulock; Jan Rupp; Katja Gueinzius; Matthias Maass; Corinna Hermann

doi:10.1128/CDLI.12.10.1254-1256.2005

Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression

Sonja Von Aulock, Jan Rupp, Katja Gueinzius, Matthias Maass, Corinna Hermann^*

^*Korrespondierende/r Autor/-in für diese Arbeit

7 Zitate (Scopus)

Abstract

Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

Originalsprache	Englisch
Zeitschrift	Clinical and Diagnostic Laboratory Immunology
Jahrgang	12
Ausgabenummer	10
Seiten (von - bis)	1254-1256
Seitenumfang	3
ISSN	1071-412X
DOIs	https://doi.org/10.1128/CDLI.12.10.1254-1256.2005
Publikationsstatus	Veröffentlicht - 01.10.2005

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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abstract = "Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.",

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Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression. / Von Aulock, Sonja; Rupp, Jan; Gueinzius, Katja et al.
in: Clinical and Diagnostic Laboratory Immunology, Jahrgang 12, Nr. 10, 01.10.2005, S. 1254-1256.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Critical investigation of the CD14 promoter polymorphism

T2 - Lack of a role for in vitro cytokine response and membrane CD14 expression

AU - Von Aulock, Sonja

AU - Rupp, Jan

AU - Gueinzius, Katja

AU - Maass, Matthias

AU - Hermann, Corinna

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

AB - Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

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DO - 10.1128/CDLI.12.10.1254-1256.2005

M3 - Journal articles

C2 - 16210494

AN - SCOPUS:26944479246

SN - 1071-412X

VL - 12

SP - 1254

EP - 1256

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

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ER -

Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression

Abstract

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