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Corrigendum to: Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants (Human Mutation, (2018), 39, 12, (1901-1915), 10.1002/humu.23602)

Franca Vulinovic, Victor Krajka, Torben J. Hausrat, Philip Seibler, Daniel Alvarez-Fischer, Harutyun Madoev, Jin Sung Park, Kishore R. Kumar, Carolyn M. Sue, Katja Lohmann, Matthias Kneussel, Christine Klein, Aleksandar Rakovic

Abstract

The article to which this Corrigendum refers was published in Human Mutation 39(12): 1901–1915 (https://doi.org/10.1002/humu.23602). Authentication analysis at Coriell Institute for Medical Research (Camden, NJ) revealed that the iPSC line named HFF in the article was not derived from a control individual but from cells of a female patient with osteogenesis imperfecta (GM17602/GM17604), carrier of a heterozygous missense mutation (p.G700C; NM_000089) in the COL1A2 gene. Differentiated neurons from HFF were genome-edited and used to examine mitochondrial transport in iPSC-derived neurons in figure 6. For these experiments, the line was used as an isogenic pair with and without heterozygous TUBB4A knockout. Mutations in the COL1A2 gene have not been associated with neurodegenerative diseases and the symptoms of neurological movement disorders have not been described for osteogenesis imperfecta. Therefore, the correction does not alter the interpretation of the results as discussed in the paper. The authors wish to apologize for the incorrect description of an iPSC line in the paper.

OriginalspracheEnglisch
ZeitschriftHuman Mutation
Jahrgang40
Ausgabenummer12
Seiten (von - bis)2444
Seitenumfang1
ISSN1059-7794
DOIs
PublikationsstatusVeröffentlicht - 01.12.2019

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

  1. SDG 3 – Gesundheit und Wohlergehen
    SDG 3 – Gesundheit und Wohlergehen
  2. SDG 10 – Weniger Ungleichheiten
    SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

  • Querschnittsbereich: Medizinische Genetik

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