Correlation of DNA mismatch repair protein hMSH2 immunohistochemistry with p53 and apoptosis in cervical carcinoma

Frank Köster*, Andreas Schröer, Dorothea Fischer, Thomas Greweldinger, Klaus Diedrich, Michael Friedrich

*Korrespondierende/r Autor/-in für diese Arbeit
7 Zitate (Scopus)

Abstract

Background: Mutations in genes of the DNA mismatch repair system (MMR) are linked to hereditary non-polyposis colorectal cancer and also play a role in sporadic cancer. Besides its repair function, the MMR is the linkage of DNA mismatch recognition to the cell cycle control. Materials and Methods: The correlation between the immunoreactivity of the MMR protein hMSH2 and p53, apoptosis, clinical prognosis factors and the survival rate in 102 samples of cervical carcinoma was determined. Results: hMSH2 immunoreactivity was correlated with p53 and weakly correlated with apoptosis. hMSH2 immunoreactivity could not be correlated to any tumour markers, while apoptosis correlated significantly with T stage, FIGO classification and the relative risk of death from cervical cancer. Conclusion: In cervical cancer, the processes of DNA mismatch repair, cell cycle control and apoptosis seemingly act in concert. Decreased expression of the hMSH2 mismatch repair protein might lead to a failure in the induction of apoptosis.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang27
Ausgabenummer1 A
Seiten (von - bis)63-68
Seitenumfang6
ISSN0250-7005
PublikationsstatusVeröffentlicht - 01.01.2007

Strategische Forschungsbereiche und Zentren

  • Profilbereich: Lübeck Integrated Oncology Network (LION)

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