Correction: Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells (Laboratory Investigation, (2021), 101, 1, (70-88), 10.1038/s41374-020-00485-2)

Three different clarifications are warranted to better understand our findings and conclusions. (1) On page 9 in the PDF version, subtitle “Medium acidification has less influence on Ca²⁺ regulation” should instead read: Role of Asc-induced acidification in increasing Ca²⁺ influx Section summary clarification: The role was reevaluated of Asc-induced medium acidification in contributing to increases in Ca²⁺ influx. We wish to clarify that the responses to Asc were much larger than those induced by medium acidification. Therefore, lowering the pH does not account for how Asc increases intracellular Ca²⁺ influx. (2) Subtitle for Fig. 10 should be corrected as: Acidifying-induced Ca²⁺ transients in etoposide-resistant and -sensitive WERI-Rb1 cells (3) The following alteration is more precise regarding the role of TRPV1 channel activation during medium acidification. (page 11 - paragraph 2 and page 14 - paragraph 3; PDF version): Section summary clarification: TRPV1 activation does not contribute to the small increases in Ca²⁺ influx resulting from medium acidification. This channel is not involved since the decline in pH occurred over a range known not to alter its activity. We suggest that mechanisms other than acidification are the main contributors underlying Asc–induced Ca²⁺ transients. Moreover, WERI-Rb1 cells possibly possess other pH sensitive pathways since lowering the pH induced significant increases in Ca²⁺ influx. These corrections do not affect the results and conclusions of the article. All authors agree with the corrections.