Contexts of care for people with differences of sex development: Diversity is still missing in the laboratory routine

Alexandra E. Kulle*, Martina Jürgensen, Ulla Döhnert, Lisa Malich, Louise Marshall, Olaf Hiort

*Korrespondierende/r Autor/-in für diese Arbeit


The 2006 Chicago consensus statement of management of disorders/difference of sex development (DSD) has achieved advantages in clinical care and diagnosis for patients and families affect by DSD. This article provides a brief overview of contexts of care for physicians, and points out specific challenges in clinical practice that have arisen from the transformations of the sex/gender system in recent years. We focus on the impact of diagnosis and laboratory measurements. Both laboratory measurements and hormonal therapies still depend on the binary system. One problem is the lack of reference intervals for the different forms of DSD, which means that diversity is often neglected. In the following, we will give a brief insight into this complex topic.

ZeitschriftMedizinische Genetik
Seiten (von - bis)181-187
PublikationsstatusVeröffentlicht - 01.09.2023

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
  • Querschnittsbereich: Medizinische Genetik


  • 205-20 Kinder- und Jugendmedizin
  • 205-17 Endokrinologie, Diabetologie, Metabolismus