Computer- and robot-assisted stereotaxy for high-precision small animal brain exploration

L. Ramrath; S. Vogt; W. Jensen; A. Schweikard; U.G. Hofmann

doi:10.1515/BMT.2009.002

Computer- and robot-assisted stereotaxy for high-precision small animal brain exploration

Titel in Übersetzung: Computer- und robotergestützte Stereotaxie für hochpräzise Exploration des Kleintierhirns

L. Ramrath, S. Vogt, W. Jensen, A. Schweikard, U.G. Hofmann

University of Aalborg

10 Zitate (Scopus)

Abstract

Dieser Beitrag stellt eine computer- und robotergestützte Umgebung für stereotaktische Eingriffe am Kleintier vor. Zwei Bestandteile der Umgebung werden im Detail vorgestellt: ein robotischer Assistent und die Softwareumgebung, um Instrumente im Kleintierhirn einzubringen. Letztere integriert dabei Module zur Registrierung, Steuerung des stereotaktischen Assistenten und zur Planung des Eingriffs. Zwei Optionen für die Planung werden vorgestellt: (a) atlasbasierte und (b) bildbasierte Planung auf Basis von Computertomographiedaten. Die Umgebung wird anhand der Einbringung von Mikroelektroden und der Akquise von elektrophysiologischen Ableitungen in vivo getestet. Konzepte zur Evaluierung der Daten im Hinblick auf eine Zuordnung einer räumlichen Position und einer neuronalen Struktur zu funktionellen Daten werden vorgestellt. Die Ergebnisse zeigen, dass die vorgestellte Umgebung präzise stereotaktische Eingriffe am Kleintier und neue Optionen in der Hirnforschung ermöglicht.

Titel in Übersetzung	Computer- und robotergestützte Stereotaxie für hochpräzise Exploration des Kleintierhirns
Originalsprache	Englisch
Zeitschrift	Biomedizinische Technik / Biomedical Engineering
Jahrgang	54
Ausgabenummer	1
Seiten (von - bis)	8-13
Seitenumfang	6
ISSN	1862-278X
DOIs	https://doi.org/10.1515/BMT.2009.002
Publikationsstatus	Veröffentlicht - 30.01.2009

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abstract = "This contribution introduces a computer- and robot-assisted framework for stereotactic neurosurgery on small animals. Two major elements of this framework are presented in detail: a robotic stereotactic assistant and the software framework for placement of probes into the brain. The latter integrates modules for registration, insertion control, and preoperative path planning. Two options for path planning are addressed: (a) atlas-based planning and (b) image-based planning based on computed tomography data. The framework is tested performing robot-assisted insertion of microelectrodes and acquisition of electrophysiological recordings in vivo. Concepts for data analysis pointing towards a mapping of position and neural structure to functional data are introduced. Results show that the presented framework allows precise small animal stereotaxy and therefore offers new options for brain research.",

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Computer- and robot-assisted stereotaxy for high-precision small animal brain exploration

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