Complement nomenclature-deconvoluted

Suzanne S. Bohlson; Peter Garred; Claudia Kemper; Andrea J. Tenner

doi:10.3389/fimmu.2019.01308

Complement nomenclature-deconvoluted

Suzanne S. Bohlson, Peter Garred, Claudia Kemper, Andrea J. Tenner^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

85 Zitate (Scopus)

Abstract

In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

Originalsprache	Englisch
Aufsatznummer	1308
Zeitschrift	Frontiers in Immunology
Jahrgang	10
Ausgabenummer	JUN
Seiten (von - bis)	1308
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2019.01308
Publikationsstatus	Veröffentlicht - 01.01.2019

Fördermittel

1Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, United States, 2Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet University Hospital of Copenhagen, Copenhagen, Denmark, 3Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States, 4Department of Molecular Biology and Biochemistry, Department of Neurobiology and Behavior, Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, United States This contribution was supported by funds from NIH National Institute of Allergy and Infectious Diseases R15AI117474-01A1 (SB), the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH (CK) as well as Danish Research Foundation of Independent Research [DFF-6110-00489], the Novo Nordisk Research Foundation and the Sven Andersen Research Foundation (PG) and NIH National Institute on Aging R01 AG060148 (AT).

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.3389/fimmu.2019.01308

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AB - In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

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Complement nomenclature-deconvoluted

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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