Complement in motion: The evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology

M. Kathryn Liszewski; Claudia Kemper

doi:10.4049/jimmunol.1900527

Complement in motion: The evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology

M. Kathryn Liszewski^*, Claudia Kemper

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

Washington University in St. Louis

32 Zitate (Scopus)

Abstract

The classic pathogen-fighting functions of our microbe sensing systems, such as the TLRs, the Nod-like receptors, and several proteins of the complement system, had been defined relatively rapidly after their discovery (1, 2). A more recent trend, however, clearly indicates that some of these evolutionarily ancient systems also serve additional, noncanonical roles in normal cell physiology. In this article, we highlight how the functions of the complement component CD46 have expanded dramatically beyond its initial discovery as a regulator of complement activation. We now recognize this ancient molecule as a biological focal point for our continuously evolving understanding of the diverse roles of complement as a key orchestrator of (immunological) health.

...

Originalsprache	Englisch
Zeitschrift	Journal of Immunology
Jahrgang	203
Ausgabenummer	1
Seiten (von - bis)	3-5
Seitenumfang	3
ISSN	0022-1767
DOIs	https://doi.org/10.4049/jimmunol.1900527
Publikationsstatus	Veröffentlicht - 01.07.2019

Fördermittel

*Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110; †Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ‡School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London, London SE1 9RT, United Kingdom; and xInstitute for Systemic Inflammation Research, University of Lubeck, 23562 Lubeck, Germany Work in the Kemper laboratory is supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health. M.K.L. support was provided by the National Institutes of Health (Grant R01 GM099111).

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Complement in motion: The evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology

Abstract

Fördermittel

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