Complement component C5 recruits neutrophils in the absence of C3 during respiratory infection with modified vaccinia virus Ankara

Philip J.R. Price, Zoltán Bánki, Angelika Scheideler, Heribert Stoiber, Admar Verschoor, Gerd Sutter, Michael H. Lehmann*

*Korrespondierende/r Autor/-in für diese Arbeit
12 Zitate (Scopus)

Abstract

Efficient leukocyte migration is important for an effective host response to viral infection and the development ofadaptive immunity. The poxvirus strain modified vaccinia virus Ankara (MVA), a safe and efficient viral vector, rapidly induces chemokine expression and respiratory recruitment of leukocytes, which is unique among vaccinia viruses. In addition to chemokines, the complement system contributes to the attraction and activation of different types of leukocytes. Using a murine model of intranasal infection, we show in this study that MVA-induced neutrophil recruitment depends on complement component C5. Remarkably, we find that C5 mediates neutrophil recruitment to the lung, even in the absence of the central complement component C3. Our findings argue for complement C5 activation during MVA infection of the lung via a C3-independent pathway, which enables rapid recruitment of neutrophils.

OriginalspracheEnglisch
ZeitschriftJournal of Immunology
Jahrgang194
Ausgabenummer3
Seiten (von - bis)1164-1168
Seitenumfang5
ISSN0022-1767
DOIs
PublikationsstatusVeröffentlicht - 01.02.2015

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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