Complement and T Cell Metabolism: Food for Thought

Erin E. West, Claudia Kemper

Abstract

The classical complement system is engrained in the mind of scientists and clinicians as a blood-operative key arm of innate immunity, critically required for the protection against invading pathogens. Recent work, however, has defined a novel and unexpected role for an intracellular complement system—the complosome—in the regulation of key metabolic events that underlie peripheral human T cell survival as well as the induction and cessation of their effector functions. This review summarizes the current knowledge about the emerging vital role of the complosome in T cell metabolism and discusses how viewing the evolution of the complement system from an “unconventional” vantage point could logically account for the development of its metabolic activities.

OriginalspracheEnglisch
ZeitschriftImmunometabolism
Jahrgang1
Ausgabenummer1
Seiten (von - bis)e190006
Seitenumfang19
ISSN2633-0407
DOIs
PublikationsstatusVeröffentlicht - 21.06.2019

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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