Co-occurence of restless legs syndrome and Parkin mutations in two families

Susana Adel; Ana Djarmati; Kemal Kabakci; Irene Pichler; Cordula Eskelson; Thora Lohnau; Norman Kock; Katja Hedrich; Eberhard Schwinger; Patricia L. Kramer; Peter P. Pramstaller; Christine Klein

doi:10.1002/mds.20690

Co-occurence of restless legs syndrome and Parkin mutations in two families

Susana Adel, Ana Djarmati, Kemal Kabakci, Irene Pichler, Cordula Eskelson, Thora Lohnau, Norman Kock, Katja Hedrich, Eberhard Schwinger, Patricia L. Kramer, Peter P. Pramstaller, Christine Klein^*

^*Korrespondierende/r Autor/-in für diese Arbeit

26 Zitate (Scopus)

Abstract

Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

Originalsprache	Englisch
Zeitschrift	Movement Disorders
Jahrgang	21
Ausgabenummer	2
Seiten (von - bis)	258-263
Seitenumfang	6
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.20690
Publikationsstatus	Veröffentlicht - 01.02.2006

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title = "Co-occurence of restless legs syndrome and Parkin mutations in two families",

abstract = "Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.",

author = "Susana Adel and Ana Djarmati and Kemal Kabakci and Irene Pichler and Cordula Eskelson and Thora Lohnau and Norman Kock and Katja Hedrich and Eberhard Schwinger and Kramer, {Patricia L.} and Pramstaller, {Peter P.} and Christine Klein",

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doi = "10.1002/mds.20690",

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AU - Adel, Susana

AU - Djarmati, Ana

AU - Kabakci, Kemal

AU - Pichler, Irene

AU - Eskelson, Cordula

AU - Lohnau, Thora

AU - Kock, Norman

AU - Hedrich, Katja

AU - Schwinger, Eberhard

AU - Kramer, Patricia L.

AU - Pramstaller, Peter P.

AU - Klein, Christine

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

AB - Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

UR - http://www.scopus.com/inward/record.url?scp=33644965265&partnerID=8YFLogxK

U2 - 10.1002/mds.20690

DO - 10.1002/mds.20690

M3 - Journal articles

C2 - 16161156

AN - SCOPUS:33644965265

SN - 0885-3185

VL - 21

SP - 258

EP - 263

JO - Movement Disorders

JF - Movement Disorders

IS - 2

ER -

Co-occurence of restless legs syndrome and Parkin mutations in two families

Abstract

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