CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease

Carmen Noelker; Vanessa Stuckenholz; Jens Peter Reese; Daniel Alvarez-Fischer; Roman Sankowski; Tanja Rausch; Wolfgang H. Oertel; Andreas Hartmann; Sonya Van Patten; Yousef Al-Abed; Michael Bacher

doi:10.1159/000342714

CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease

Carmen Noelker, Vanessa Stuckenholz, Jens Peter Reese, Daniel Alvarez-Fischer, Roman Sankowski, Tanja Rausch, Wolfgang H. Oertel, Andreas Hartmann, Sonya Van Patten, Yousef Al-Abed, Michael Bacher^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Psychiatrie und Psychotherapie

12 Zitate (Scopus)

Abstract

Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons in the substantia nigra. Neuroinflammatory processes have been shown to be a key component of this neurodegeneration and, as such, small molecule compounds which inhibit these inflammatory events are a critical research focus.

Originalsprache	Englisch
Zeitschrift	Neurodegenerative Diseases
Jahrgang	12
Ausgabenummer	2
Seiten (von - bis)	103-110
Seitenumfang	8
ISSN	1660-2854
DOIs	https://doi.org/10.1159/000342714
Publikationsstatus	Veröffentlicht - 2013

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SDG 3 – Gesundheit und Wohlergehen
SDG 10 – Weniger Ungleichheiten

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1159/000342714

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Noelker, C., Stuckenholz, V., Reese, J. P., Alvarez-Fischer, D., Sankowski, R., Rausch, T., Oertel, W. H., Hartmann, A., Van Patten, S., Al-Abed, Y., & Bacher, M. (2013). CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease. Neurodegenerative Diseases, 12(2), 103-110. https://doi.org/10.1159/000342714

@article{39aa382a1ad44fc2b62dbb9bb89f5eaf,

title = "CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease",

abstract = "Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons in the substantia nigra. Neuroinflammatory processes have been shown to be a key component of this neurodegeneration and, as such, small molecule compounds which inhibit these inflammatory events are a critical research focus.",

author = "Carmen Noelker and Vanessa Stuckenholz and Reese, \{Jens Peter\} and Daniel Alvarez-Fischer and Roman Sankowski and Tanja Rausch and Oertel, \{Wolfgang H.\} and Andreas Hartmann and \{Van Patten\}, Sonya and Yousef Al-Abed and Michael Bacher",

note = "Publisher Copyright: Copyright {\textcopyright} 2012 S. Karger AG, Basel.",

year = "2013",

doi = "10.1159/000342714",

language = "English",

volume = "12",

pages = "103--110",

journal = "Neurodegenerative Diseases",

issn = "1660-2854",

publisher = "S. Karger AG",

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Noelker, C, Stuckenholz, V, Reese, JP, Alvarez-Fischer, D, Sankowski, R, Rausch, T, Oertel, WH, Hartmann, A, Van Patten, S, Al-Abed, Y & Bacher, M 2013, 'CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease', Neurodegenerative Diseases, Jg. 12, Nr. 2, S. 103-110. https://doi.org/10.1159/000342714

TY - JOUR

T1 - CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease

AU - Noelker, Carmen

AU - Stuckenholz, Vanessa

AU - Reese, Jens Peter

AU - Alvarez-Fischer, Daniel

AU - Sankowski, Roman

AU - Rausch, Tanja

AU - Oertel, Wolfgang H.

AU - Hartmann, Andreas

AU - Van Patten, Sonya

AU - Al-Abed, Yousef

AU - Bacher, Michael

PY - 2013

Y1 - 2013

N2 - Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons in the substantia nigra. Neuroinflammatory processes have been shown to be a key component of this neurodegeneration and, as such, small molecule compounds which inhibit these inflammatory events are a critical research focus.

AB - Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons in the substantia nigra. Neuroinflammatory processes have been shown to be a key component of this neurodegeneration and, as such, small molecule compounds which inhibit these inflammatory events are a critical research focus.

UR - https://www.scopus.com/pages/publications/84881175042

U2 - 10.1159/000342714

DO - 10.1159/000342714

M3 - Journal articles

C2 - 23147695

AN - SCOPUS:84881175042

SN - 1660-2854

VL - 12

SP - 103

EP - 110

JO - Neurodegenerative Diseases

JF - Neurodegenerative Diseases

IS - 2

ER -

CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease

Abstract

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