Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany)

VERGE Study Group; Tobias Wengenmayer; Dawid L Staudacher; Alois Philipp; Eike Tigges; Angela Dettling; Hendrik Busse; Marc Kriege; Jan-Sören Padberg; Ingo Voigt; Clemens Scherer; Tobias Graf; Dominik Scharpf; Peter Noack; Simone Britsch; Guido Michels

doi:10.1007/s00392-025-02650-3

Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany)

VERGE Study Group, Tobias Wengenmayer, Dawid L Staudacher, Alois Philipp, Eike Tigges, Angela Dettling, Hendrik Busse, Marc Kriege, Jan-Sören Padberg, Ingo Voigt, Clemens Scherer, Tobias Graf, Dominik Scharpf, Peter Noack, Simone Britsch, Guido Michels

Medizinische Klinik II

1 Zitat (Scopus)

Abstract

The VA ECMO Registry of Germany (VERGE, http://va-ecmo-register.de/ ) is a prospective, multicenter, investigator-driven registry of Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) all-comers, free from industrial support. VERGE is Germany's first multicenter registry to systematically gather and analyze data from various centers on the clinical use of VA ECMO. This first report compromises data from 581 VA ECMO patients from 2022. Median age was 60 years, hospital survival was 42% and 25% were female. The leading indication for VA ECMO was extracorporeal cardiopulmonary resuscitation (ECPR) followed by VA ECMO in shock (48.9 and 34.9%, respectively). Hospital survival of ECPR was significantly worse compared to shock (28 and 55%, respectively, p < 0.001). Age, pH, and lactate before cannulation all significantly correlated independently with hospital survival (p < 0.001). In VERGE, no patients with pH below 6.7 or lactate above 25 mmol/l survived.

Originalsprache	Englisch
Aufsatznummer	102619
Zeitschrift	Clinical Research in Cardiology
Jahrgang	114
Ausgabenummer	10
Seiten (von - bis)	1377-1387
Seitenumfang	11
ISSN	1861-0684
DOIs	https://doi.org/10.1007/s00392-025-02650-3
Publikationsstatus	Veröffentlicht - 2025

Fördermittel

We thank all the participating centers, healthcare professionals, and administrative staff involved in this national effort. VERGE was supported by the ministry of Science, Research and Arts Baden-W\u00FCrttemberg. We thank Achim Lother for contributing with BioRender to the graphical abstract. VERGE Studygroup: Dirk Lunz, Department of Anesthesiology, University Hospital Regensburg, Germany and Thomas M\u00FCller, Department of Internal Medicine II, University Hospital Regensburg, Germany. Adrian Springer and Piotr Foszcz, Asklepios Clinic St. Georg, Cardiology and Critical Care, Hamburg, Germany and DZHK\u2014Deutsches Zentrum f\u00FCr Herz-Kreislauf-Forschung, Germany. Benedikt Schrage (Department of Cardiology) and Stefan Kluge (Department of Intensive Care Medicine), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Alexander Supady, Interdisciplinary Medical Intensive Care (IMIT), Faculty of Medicine and Medical Center, University of Freiburg, Germany and Sven Maier, Department of Cardiovascular Surgery, Faculty of Medicine and Medical Center, University of Freiburg, Germany. Aiman Alken, Heart and Vascular Center Bad Bevensen, Bad Bevensen, Germany. Ingo Sagoschen, Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University Mainz, Germany. Felix Rosenow and Jan Sackarnd, Department for Cardiology I: Coronary and Periphereal Vascular Disease, Heart Failure, University Hospital M\u00FCnster, Germany. Stefan Leinen, Department of Emergency Medicine, Hospital of the Barmherzige Br\u00FCder, Trier, Germany. Felix Michelson und Jan-Philipp Simon, Department of Medicine I, LMU University Hospital, LMU Munich, Germany. Sven Siemonsen und Sebastian Becker, Department of Cardiology, Intensive Care Medicine, Klinikum N\u00FCrnberg, Paracelsus Medical University, Nuremberg, Germany. Sverrir M\u00F6ller, University Heart Center L\u00FCbeck, Germany. Marcus Hennersdorf and Sebastian M\u00FCnz, SLK-Kliniken Heilbronn GmbH, Klinikum Am Gesundbrunnen, Medical Department I, Heilbronn, Germany. Simone Britsch und Simon Lindner (German Centre for Cardiovascular Research (DZHK), Mannheim, Germany; European Centre for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Emergency Medicine, Hospital of the Barmherzige Br\u00FCder, Trier, Germany)

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Zentren: Universitäres Herzzentrum Lübeck (UHZL)

DFG-Fachsystematik

2.22-12 Kardiologie, Angiologie

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10.1007/s00392-025-02650-3

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VERGE Study Group, Wengenmayer, T., Staudacher, D. L., Philipp, A., Tigges, E., Dettling, A., Busse, H., Kriege, M., Padberg, J.-S., Voigt, I., Scherer, C., Graf, T., Scharpf, D., Noack, P., Britsch, S., & Michels, G. (2025). Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany). Clinical Research in Cardiology, 114(10), 1377-1387. Artikel 102619. https://doi.org/10.1007/s00392-025-02650-3

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abstract = "The VA ECMO Registry of Germany (VERGE, http://va-ecmo-register.de/ ) is a prospective, multicenter, investigator-driven registry of Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) all-comers, free from industrial support. VERGE is Germany's first multicenter registry to systematically gather and analyze data from various centers on the clinical use of VA ECMO. This first report compromises data from 581 VA ECMO patients from 2022. Median age was 60 years, hospital survival was 42\% and 25\% were female. The leading indication for VA ECMO was extracorporeal cardiopulmonary resuscitation (ECPR) followed by VA ECMO in shock (48.9 and 34.9\%, respectively). Hospital survival of ECPR was significantly worse compared to shock (28 and 55\%, respectively, p < 0.001). Age, pH, and lactate before cannulation all significantly correlated independently with hospital survival (p < 0.001). In VERGE, no patients with pH below 6.7 or lactate above 25 mmol/l survived.",

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doi = "10.1007/s00392-025-02650-3",

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VERGE Study Group, Wengenmayer, T, Staudacher, DL, Philipp, A, Tigges, E, Dettling, A, Busse, H, Kriege, M, Padberg, J-S, Voigt, I, Scherer, C, Graf, T, Scharpf, D, Noack, P, Britsch, S & Michels, G 2025, 'Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany)', Clinical Research in Cardiology, Jg. 114, Nr. 10, 102619, S. 1377-1387. https://doi.org/10.1007/s00392-025-02650-3

Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany). / VERGE Study Group; Wengenmayer, Tobias; Staudacher, Dawid L et al.
in: Clinical Research in Cardiology, Jahrgang 114, Nr. 10, 102619, 2025, S. 1377-1387.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO)

T2 - insights from VERGE (VA ECMO Registry of Germany)

AU - VERGE Study Group

AU - Wengenmayer, Tobias

AU - Staudacher, Dawid L

AU - Philipp, Alois

AU - Tigges, Eike

AU - Dettling, Angela

AU - Busse, Hendrik

AU - Kriege, Marc

AU - Padberg, Jan-Sören

AU - Voigt, Ingo

AU - Scherer, Clemens

AU - Graf, Tobias

AU - Scharpf, Dominik

AU - Noack, Peter

AU - Britsch, Simone

AU - Michels, Guido

PY - 2025

Y1 - 2025

N2 - The VA ECMO Registry of Germany (VERGE, http://va-ecmo-register.de/ ) is a prospective, multicenter, investigator-driven registry of Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) all-comers, free from industrial support. VERGE is Germany's first multicenter registry to systematically gather and analyze data from various centers on the clinical use of VA ECMO. This first report compromises data from 581 VA ECMO patients from 2022. Median age was 60 years, hospital survival was 42% and 25% were female. The leading indication for VA ECMO was extracorporeal cardiopulmonary resuscitation (ECPR) followed by VA ECMO in shock (48.9 and 34.9%, respectively). Hospital survival of ECPR was significantly worse compared to shock (28 and 55%, respectively, p < 0.001). Age, pH, and lactate before cannulation all significantly correlated independently with hospital survival (p < 0.001). In VERGE, no patients with pH below 6.7 or lactate above 25 mmol/l survived.

AB - The VA ECMO Registry of Germany (VERGE, http://va-ecmo-register.de/ ) is a prospective, multicenter, investigator-driven registry of Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) all-comers, free from industrial support. VERGE is Germany's first multicenter registry to systematically gather and analyze data from various centers on the clinical use of VA ECMO. This first report compromises data from 581 VA ECMO patients from 2022. Median age was 60 years, hospital survival was 42% and 25% were female. The leading indication for VA ECMO was extracorporeal cardiopulmonary resuscitation (ECPR) followed by VA ECMO in shock (48.9 and 34.9%, respectively). Hospital survival of ECPR was significantly worse compared to shock (28 and 55%, respectively, p < 0.001). Age, pH, and lactate before cannulation all significantly correlated independently with hospital survival (p < 0.001). In VERGE, no patients with pH below 6.7 or lactate above 25 mmol/l survived.

UR - https://www.scopus.com/pages/publications/105003406500

UR - https://www.mendeley.com/catalogue/5c191b6b-a820-39a1-86c9-469ad5a2c32a/

U2 - 10.1007/s00392-025-02650-3

DO - 10.1007/s00392-025-02650-3

M3 - Journal articles

C2 - 40261425

SN - 1861-0684

VL - 114

SP - 1377

EP - 1387

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

IS - 10

M1 - 102619

ER -

Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany)

Abstract

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