Clinical outcome in patients with obsessive-compulsive disorder after discontinuation of SRI treatment: Results from a two-year follow-up

Andreas Kordon*, Kai G. Kahl, Andreas Broocks, Ulrich Voderholzer, Hildegard Rasche-Räuchle, Fritz Hohagen

*Korrespondierende/r Autor/-in für diese Arbeit
27 Zitate (Scopus)

Abstract

Background: Combined treatment with serotonin-reuptake inhibitors (SRI) and cognitive-behavioral therapy (CBT) is a common therapy approach for obsessive-compulsive disorder (OCD). However, it is a matter of debate whether discontinuation of SRI after combined treatment leads to relapse. Method: Seventy-four consecutively admitted patients suffering from OCD were included in the study. Thirty-seven patients were treated with CBT alone, and 37 patients received combined CBT and SRI treatment. Of these latter patients, seventeen discontinued SRI treatment during the follow-up period (1 and 2 years after inpatient treatment). OCD symptom severity was determined by Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and mood was assessed by Hamilton Depression Rating Scale (HDRS). Results: During the initial treatment, scores for Y-BOCS (p < 0.001), HDRS (p < 0.001) and the Global Assessment of Functioning Scale (GAF) (p < 0.001) improved significantly in all groups. Reassessment two years later revealed that a) OCD symptom severity and depression scores were similar between the groups and b) discontinuation of SRI did not prompt by a recurrence of symptoms. Conclusions: We interpret our results as suggesting that discontinuation of SRI treatment may be considered in formerly combined treated OCD patients after stable remission.

OriginalspracheEnglisch
ZeitschriftEuropean Archives of Psychiatry and Clinical Neuroscience
Jahrgang255
Ausgabenummer1
Seiten (von - bis)48-50
Seitenumfang3
ISSN0940-1334
DOIs
PublikationsstatusVeröffentlicht - 02.2005

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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