Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Klaus Peter Wandinger; Peter Trillenberg; Harald Klüter; Karl Wessel; Holger Kirchner

doi:10.1016/S0967-5868(99)90027-9

Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Klaus Peter Wandinger^*, Peter Trillenberg, Harald Klüter, Karl Wessel, Holger Kirchner

^*Korrespondierende/r Autor/-in für diese Arbeit

6 Zitate (Scopus)

Abstract

The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.

Originalsprache	Englisch
Zeitschrift	Journal of Clinical Neuroscience
Jahrgang	6
Ausgabenummer	5
Seiten (von - bis)	373-374
Seitenumfang	2
ISSN	0967-5868
DOIs	https://doi.org/10.1016/S0967-5868(99)90027-9
Publikationsstatus	Veröffentlicht - 01.01.1999

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Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 10 – Weniger Ungleichheiten

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/S0967-5868(99)90027-9

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abstract = "The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.",

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AU - Wandinger, Klaus Peter

AU - Trillenberg, Peter

AU - Klüter, Harald

AU - Wessel, Karl

AU - Kirchner, Holger

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.

AB - The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.

UR - https://www.scopus.com/pages/publications/0009676995

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DO - 10.1016/S0967-5868(99)90027-9

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JO - Journal of Clinical Neuroscience

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IS - 5

ER -

Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Abstract

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