Circulating tumour cells in breast cancer

Natalia Krawczyk; Malgorzata Banys; Andreas Hartkopf; Carsten Hagenbeck; Carola Melcher; Tanja Fehm

doi:10.3332/ecancer.2013.352

Circulating tumour cells in breast cancer

Natalia Krawczyk, Malgorzata Banys, Andreas Hartkopf, Carsten Hagenbeck, Carola Melcher, Tanja Fehm

Klinik für Frauenheilkunde und Geburtshilfe

14 Zitate (Scopus)

Abstract

Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies. Copyright:

Originalsprache	Englisch
Aufsatznummer	352
Zeitschrift	ecancermedicalscience
Jahrgang	7
Ausgabenummer	1
DOIs	https://doi.org/10.3332/ecancer.2013.352
Publikationsstatus	Veröffentlicht - 19.09.2013

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We acknowledge the support of the Breast Cancer Campaign (grant 2001/243) and the Breast Cancer Research Trust. We thank Lila Zabaglo for her help in preparation of this review.

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10.3332/ecancer.2013.352

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title = "Circulating tumour cells in breast cancer",

abstract = "Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40\% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies. Copyright:",

author = "Natalia Krawczyk and Malgorzata Banys and Andreas Hartkopf and Carsten Hagenbeck and Carola Melcher and Tanja Fehm",

note = "Funding Information: We acknowledge the support of the Breast Cancer Campaign (grant 2001/243) and the Breast Cancer Research Trust. We thank Lila Zabaglo for her help in preparation of this review. ",

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AU - Krawczyk, Natalia

AU - Banys, Malgorzata

AU - Hartkopf, Andreas

AU - Hagenbeck, Carsten

AU - Melcher, Carola

AU - Fehm, Tanja

N1 - Funding Information: We acknowledge the support of the Breast Cancer Campaign (grant 2001/243) and the Breast Cancer Research Trust. We thank Lila Zabaglo for her help in preparation of this review.

PY - 2013/9/19

Y1 - 2013/9/19

N2 - Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies. Copyright:

AB - Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies. Copyright:

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DO - 10.3332/ecancer.2013.352

M3 - Scientific review articles

AN - SCOPUS:84887831899

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VL - 7

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ER -

Circulating tumour cells in breast cancer

Abstract

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