TY - JOUR
T1 - Circulating tumour cells in breast cancer
AU - Krawczyk, Natalia
AU - Banys, Malgorzata
AU - Hartkopf, Andreas
AU - Hagenbeck, Carsten
AU - Melcher, Carola
AU - Fehm, Tanja
N1 - Funding Information:
We acknowledge the support of the Breast Cancer Campaign (grant 2001/243) and the Breast Cancer Research Trust. We thank Lila Zabaglo for her help in preparation of this review.
PY - 2013/9/19
Y1 - 2013/9/19
N2 - Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies. Copyright:
AB - Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies. Copyright:
UR - http://www.scopus.com/inward/record.url?scp=84887831899&partnerID=8YFLogxK
U2 - 10.3332/ecancer.2013.352
DO - 10.3332/ecancer.2013.352
M3 - Scientific review articles
AN - SCOPUS:84887831899
SN - 1754-6605
VL - 7
JO - ecancermedicalscience
JF - ecancermedicalscience
IS - 1
M1 - 352
ER -
