Chlamydophila pneumoniae. Mechanisms of target cell infection and activation

Matthias Krüll*, Matthias Maass, Norbert Suttorp, Jan Rupp

*Korrespondierende/r Autor/-in für diese Arbeit
    37 Zitate (Scopus)


    Chlamydophila (Chlamydia) pneumoniae, a gram-negative obligate intracellular bacterium, is a widespread respiratory pathogen. Chronic C. pneumoniae infection has been suggested as a trigger/promoter of inflammation that may result in vascular lesions. Although the genome of C. pneumoniae has been sequenced completely this information has not yet led to an understanding of the mechanisms of acute infection and target cell activation nor to the identification of potential chlamydial virulence factors. Intriguingly, current antibiotic treatment options for acute chlamydial infection were proven to be ineffective with respect to clinical outcome in different groups of atherosclerotic patients. The reason might be that primary infection of vascular smooth muscle cells and blood monocytes with C. pneumoniae resembles rather a persistent, antibiotic-resistant, than an active infection. In this review we will focus on the importance of putative host cell receptors for C. pneumoniae and subsequently activated signal transduction pathways.

    ZeitschriftThrombosis and Haemostasis
    Seiten (von - bis)319-326
    PublikationsstatusVeröffentlicht - 01.08.2005

    Strategische Forschungsbereiche und Zentren

    • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)


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