Characterization of Micro- and Nanoscale LuPO4: Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy

Sara Espinoza; Matthias Müller; Heike Jenneboer; Lukas Peulen; Tiara Bradley; Martin Purschke; Markus Haase; Ramtin Rahmanzadeh; Thomas Jüstel

doi:10.1002/ppsc.201900280

Characterization of Micro- and Nanoscale LuPO₄: Pr³⁺,Nd³⁺ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy

Sara Espinoza^*, Matthias Müller, Heike Jenneboer, Lukas Peulen, Tiara Bradley, Martin Purschke, Markus Haase, Ramtin Rahmanzadeh, Thomas Jüstel

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biomedizinische Optik

25 Zitate (Scopus)

Abstract

UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd³⁺ concentrations on the UV-C emission of micro- and nanoscale LuPO₄:Pr³⁺ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO₄ results in increased UV-C emission independent of excitation source due to energy transfer from Nd³⁺ to Pr³⁺. The highest UV-C emission intensity is observed for LuPO₄:Pr³⁺,Nd³⁺(1%,2.5%) upon X-ray irradiation. Finally, LuPO₄ NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach.

Originalsprache	Englisch
Aufsatznummer	1900280
Zeitschrift	Particle and Particle Systems Characterization
Jahrgang	36
Ausgabenummer	10
ISSN	0934-0866
DOIs	https://doi.org/10.1002/ppsc.201900280
Publikationsstatus	Veröffentlicht - 01.10.2019

Fördermittel

S.E. and M.M. contributed equally to this work. The authors are grateful to the Muenster University of Applied Sciences for the Gender Equality Grant and to the Bullock Postdoctoral Fellowship at the Wellman Center for Photomedicine for the financial support which funded this research. The authors also thank H. Eickmeier for the TEM images.

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Forschungsschwerpunkt: Biomedizintechnik

Dokumente

10.1002/ppsc.201900280

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Espinoza, S., Müller, M., Jenneboer, H., Peulen, L., Bradley, T., Purschke, M., Haase, M., Rahmanzadeh, R., & Jüstel, T. (2019). Characterization of Micro- and Nanoscale LuPO₄: Pr³⁺,Nd³⁺ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy. Particle and Particle Systems Characterization, 36(10), Artikel 1900280. https://doi.org/10.1002/ppsc.201900280

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title = "Characterization of Micro- and Nanoscale LuPO4: Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy",

abstract = "UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV-C emission of micro- and nanoscale LuPO4:Pr3+ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO4 results in increased UV-C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV-C emission intensity is observed for LuPO4:Pr3+,Nd3+(1\%,2.5\%) upon X-ray irradiation. Finally, LuPO4 NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach.",

author = "Sara Espinoza and Matthias M{\"u}ller and Heike Jenneboer and Lukas Peulen and Tiara Bradley and Martin Purschke and Markus Haase and Ramtin Rahmanzadeh and Thomas J{\"u}stel",

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Characterization of Micro- and Nanoscale LuPO₄: Pr³⁺,Nd³⁺ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy. / Espinoza, Sara; Müller, Matthias; Jenneboer, Heike et al.
in: Particle and Particle Systems Characterization, Jahrgang 36, Nr. 10, 1900280, 01.10.2019.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Characterization of Micro- and Nanoscale LuPO4: Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy

AU - Espinoza, Sara

AU - Müller, Matthias

AU - Jenneboer, Heike

AU - Peulen, Lukas

AU - Bradley, Tiara

AU - Purschke, Martin

AU - Haase, Markus

AU - Rahmanzadeh, Ramtin

AU - Jüstel, Thomas

PY - 2019/10/1

Y1 - 2019/10/1

N2 - UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV-C emission of micro- and nanoscale LuPO4:Pr3+ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO4 results in increased UV-C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV-C emission intensity is observed for LuPO4:Pr3+,Nd3+(1%,2.5%) upon X-ray irradiation. Finally, LuPO4 NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach.

AB - UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV-C emission of micro- and nanoscale LuPO4:Pr3+ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO4 results in increased UV-C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV-C emission intensity is observed for LuPO4:Pr3+,Nd3+(1%,2.5%) upon X-ray irradiation. Finally, LuPO4 NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach.

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