Cerebellar rTMS and PAS effectively induce cerebellar plasticity

Martje G. Pauly; Annika Steinmeier; Christina Bolte; Feline Hamami; Elinor Tzvi; Alexander Münchau; Tobias Bäumer; Anne Weissbach

doi:10.1038/s41598-021-82496-7

Cerebellar rTMS and PAS effectively induce cerebellar plasticity

Martje G. Pauly, Annika Steinmeier, Christina Bolte, Feline Hamami, Elinor Tzvi, Alexander Münchau, Tobias Bäumer, Anne Weissbach^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Universität Leipzig

28 Zitate (Scopus)

Abstract

Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasticity and gain insights into the interaction of the cerebellum with neo-cortical structures including the motor cortex. We compared the effects of 1 Hz rTMS, cTBS, PAS and tDCS given over the cerebellum on motor cortical excitability and interactions between the cerebellum and dorsal premotor cortex / primary motor cortex in two within subject designs in healthy controls. In experiment 1, rTMS, cTBS, PAS, and tDCS were applied over the cerebellum in 20 healthy subjects. In experiment 2, rTMS and PAS were compared to sham conditions in another group of 20 healthy subjects. In experiment 1, PAS reduced cortical excitability determined by motor evoked potentials (MEP) amplitudes, whereas rTMS increased motor thresholds and facilitated dorsal premotor-motor and cerebellum-motor cortex interactions. TDCS and cTBS had no significant effects. In experiment 2, MEP amplitudes increased after rTMS and motor thresholds following PAS. Analysis of all participants who received rTMS and PAS showed that MEP amplitudes were reduced after PAS and increased following rTMS. rTMS also caused facilitation of dorsal premotor-motor cortex and cerebellum-motor cortex interactions. In summary, cerebellar 1 Hz rTMS and PAS can effectively induce plasticity in cerebello-(premotor)-motor pathways provided larger samples are studied.

Originalsprache	Englisch
Aufsatznummer	3070
Zeitschrift	Scientific Reports
Jahrgang	11
Ausgabenummer	1
Seiten (von - bis)	3070
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-021-82496-7
Publikationsstatus	Veröffentlicht - 04.02.2021

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This study was supported by the Deutsche Forschungsgemeinschaft (DFG, SFB 936, project C5). Open Access funding enabled and organized by Projekt DEAL. MGP, AS, FH and CB did not receive funding. ET is supported by the German Research Foundation (DFG, TZ 85/1-1). AM: Commercial research support: Pharm Allergan, Ipsen, Merz Pharmaceuticals, Actelion; Honoraria for lectures: Pharm Allergan, Ipsen, Merz Pharmaceuticals, Actelion, GlaxoSmithKline, Desitin, Teva, Takeda; Consultancies: Desitin, Merz Pharmaceuticals, Admedicum; Support from Foundations: Possehl-Stiftung (Lübeck, Germany), Margot und Jürgen Wessel Stiftung (Lübeck, Germany), Tourette Syndrome Association (Germany), Interessenverband Tourette Syndrom (Germany), CHDI, Damp-Stiftung; Academic research support: Deutsche Forschungsgemeinschaft (DFG): projects 1692/3-1, 4-1, SFB 936, and FOR 2698 (project numbers 396914663, 396577296, 396474989), Innovation-sausschuss of the Gemeinsamer Bundesausschuss: Translate NAMSE (structural support for the Lübeck Center for Rare Diseases); European Reference Network—Rare Neurological Diseases (ERN—RND); Royalties for the book Neurogenetics (Oxford University Press); Advisory Boards: German Tourette syndrome Association; Alliance of patients with chronic rare diseases. TB Commercial research support: Pharm Allergan, Ipsen, Merz Pharmaceuticals, Honoraria for lectures: Pharm Allergan, Ipsen Pharma, Merz Pharmaceuticals, Consultancies: Pharm Allergan, Ipsen Pharma, Merz Pharmaceuticals. Support from Foundations: Possehl-Stiftung (Lübeck, Germany). Academic research support: Deutsche Forschungsgemeinschaft (DFG): projects SFB 936, and FOR 2698. AW receives funding from the German Research Foundation (DFG, WE 5919/2-1) and the Else Kröner-Fresenius Foundation (2018_A55).

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Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.23-06 Molekulare und zelluläre Neurologie und Neuropathologie

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10.1038/s41598-021-82496-7

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abstract = "Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasticity and gain insights into the interaction of the cerebellum with neo-cortical structures including the motor cortex. We compared the effects of 1 Hz rTMS, cTBS, PAS and tDCS given over the cerebellum on motor cortical excitability and interactions between the cerebellum and dorsal premotor cortex / primary motor cortex in two within subject designs in healthy controls. In experiment 1, rTMS, cTBS, PAS, and tDCS were applied over the cerebellum in 20 healthy subjects. In experiment 2, rTMS and PAS were compared to sham conditions in another group of 20 healthy subjects. In experiment 1, PAS reduced cortical excitability determined by motor evoked potentials (MEP) amplitudes, whereas rTMS increased motor thresholds and facilitated dorsal premotor-motor and cerebellum-motor cortex interactions. TDCS and cTBS had no significant effects. In experiment 2, MEP amplitudes increased after rTMS and motor thresholds following PAS. Analysis of all participants who received rTMS and PAS showed that MEP amplitudes were reduced after PAS and increased following rTMS. rTMS also caused facilitation of dorsal premotor-motor cortex and cerebellum-motor cortex interactions. In summary, cerebellar 1 Hz rTMS and PAS can effectively induce plasticity in cerebello-(premotor)-motor pathways provided larger samples are studied.",

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AU - Münchau, Alexander

AU - Bäumer, Tobias

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Cerebellar rTMS and PAS effectively induce cerebellar plasticity

Abstract

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