Cell-derived sequences in the N-terminal region of the polyprotein of a cytopathogenic pestivirus

A. Müller, G. Rinck, H. J. Thiel, N. Tautz*

*Korrespondierende/r Autor/-in für diese Arbeit
21 Zitate (Scopus)

Abstract

Efficient proteolytic release of nonstructural protein 3 (NS3) from the viral polyprotein is considered to be crucial for the cytopathogenicity of pestiviruses. Here we describe a novel cytopathogenic (cp) bovine viral diarrhea virus strain (BVDV CP8) with a complex insertion composed of viral and cell-derived sequences, including two fragments of the cellular J-domain protein Jiv (J-domain protein interacting with viral protein) located in the N-terminal region of the polyprotein. BVDV CP8 expresses a Jiv fusion protein of 513 amino acids in addition to a complete set of viral proteins. This protein has the capacity to induce NS2-3 cleavage in trans. Accordingly, CP8 is a representative of a novel type of cp pestivirus with a cp-specific mutation located outside of the NS2-3 gene.

OriginalspracheEnglisch
ZeitschriftJournal of Virology
Jahrgang77
Ausgabenummer19
Seiten (von - bis)10663-10669
Seitenumfang7
ISSN0022-538X
DOIs
PublikationsstatusVeröffentlicht - 01.10.2003

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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