CD4 memory T cells on trial: immunological memory without a memory T cell

Eric B. Bell; Jürgen Westermann

doi:10.1016/j.it.2008.06.002

CD4 memory T cells on trial: immunological memory without a memory T cell

Eric B. Bell^*, Jürgen Westermann

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Anatomie

University of Manchester

39 Zitate (Scopus)

Abstract

Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.

Originalsprache	Englisch
Zeitschrift	Trends in Immunology
Jahrgang	29
Ausgabenummer	9
Seiten (von - bis)	405-411
Seitenumfang	7
ISSN	1471-4906
DOIs	https://doi.org/10.1016/j.it.2008.06.002
Publikationsstatus	Veröffentlicht - 09.2008

Fördermittel

This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1016/j.it.2008.06.002

Weitere Links

Link to publication in Scopus

Zitieren

@article{7996233b52f64770994dee8fdf37b93c,

title = "CD4 memory T cells on trial: immunological memory without a memory T cell",

abstract = "Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting na{\"i}ve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.",

author = "Bell, \{Eric B.\} and J{\"u}rgen Westermann",

note = "Funding Information: This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2008",

month = sep,

doi = "10.1016/j.it.2008.06.002",

language = "English",

volume = "29",

pages = "405--411",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Elsevier Ltd",

number = "9",

}

TY - JOUR

T1 - CD4 memory T cells on trial: immunological memory without a memory T cell

AU - Bell, Eric B.

AU - Westermann, Jürgen

N1 - Funding Information: This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2008/9

Y1 - 2008/9

N2 - Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.

AB - Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.

UR - https://www.scopus.com/pages/publications/49849105373

U2 - 10.1016/j.it.2008.06.002

DO - 10.1016/j.it.2008.06.002

M3 - Journal articles

C2 - 18674966

AN - SCOPUS:49849105373

SN - 1471-4906

VL - 29

SP - 405

EP - 411

JO - Trends in Immunology

JF - Trends in Immunology

IS - 9

ER -

CD4 memory T cells on trial: immunological memory without a memory T cell

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

Weitere Links

Fingerprint

Zitieren