Abstract
Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.
Originalsprache | Englisch |
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Zeitschrift | Trends in Immunology |
Jahrgang | 29 |
Ausgabenummer | 9 |
Seiten (von - bis) | 405-411 |
Seitenumfang | 7 |
ISSN | 1471-4906 |
DOIs | |
Publikationsstatus | Veröffentlicht - 09.2008 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)