CD14 promoter polymorphism - 159C> T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes

J. Rupp; W. Goepel; E. Kramme; J. Jahn; W. Solbach; Matthias Maass

doi:10.1038/sj.gene.6364112

CD14 promoter polymorphism - 159C> T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes

J. Rupp, W. Goepel, E. Kramme, J. Jahn, W. Solbach, Matthias Maass^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Borromaus Hospital

36 Zitate (Scopus)

Abstract

Chlamydia pneumoniae uses peripheral blood monocytes (PBMC) for systemic dissemination and has been linked to atherogenesis by inflammation mediated via TLR2/4 and CD14. We found 12.8% of 610 coronary artery disease (CAD) patients of Central European background to be chronically infected with C. pneumoniae based on the repeated detection of chlamydial DNA in PBMC. Among those the - 159C> T CD14 promoter polymorphism was more frequent (OR 1.7, 95% CI 1.08-2.65, P = 0.0224) than among C. pneumoniae-negative subjects matched for age and gender. The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydial infection. Susceptibility for chronic chlamydial infection of PBMC in CAD patients appears associated with the CD14-159C> T promoter polymorphism encoding for enhanced CD14 expression.

Originalsprache	Englisch
Zeitschrift	Genes and Immunity
Jahrgang	5
Ausgabenummer	5
Seiten (von - bis)	435-438
Seitenumfang	4
ISSN	1466-4879
DOIs	https://doi.org/10.1038/sj.gene.6364112
Publikationsstatus	Veröffentlicht - 01.08.2004

Fördermittel

This study was supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 367/B11 and SPP1130). We gratefully thank T Luedemann, A Hellberg and A. Gravenhorst (University of Luebeck) for technical assistance and A Kleensang (Institute of Medical Biometry and Statistics, University of Luebeck) for his support in data analysis.

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1038/sj.gene.6364112

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title = "CD14 promoter polymorphism - 159C> T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes",

abstract = "Chlamydia pneumoniae uses peripheral blood monocytes (PBMC) for systemic dissemination and has been linked to atherogenesis by inflammation mediated via TLR2/4 and CD14. We found 12.8\% of 610 coronary artery disease (CAD) patients of Central European background to be chronically infected with C. pneumoniae based on the repeated detection of chlamydial DNA in PBMC. Among those the - 159C> T CD14 promoter polymorphism was more frequent (OR 1.7, 95\% CI 1.08-2.65, P = 0.0224) than among C. pneumoniae-negative subjects matched for age and gender. The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydial infection. Susceptibility for chronic chlamydial infection of PBMC in CAD patients appears associated with the CD14-159C> T promoter polymorphism encoding for enhanced CD14 expression.",

author = "J. Rupp and W. Goepel and E. Kramme and J. Jahn and W. Solbach and Matthias Maass",

year = "2004",

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doi = "10.1038/sj.gene.6364112",

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T1 - CD14 promoter polymorphism - 159C> T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes

AU - Rupp, J.

AU - Goepel, W.

AU - Kramme, E.

AU - Jahn, J.

AU - Solbach, W.

AU - Maass, Matthias

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Chlamydia pneumoniae uses peripheral blood monocytes (PBMC) for systemic dissemination and has been linked to atherogenesis by inflammation mediated via TLR2/4 and CD14. We found 12.8% of 610 coronary artery disease (CAD) patients of Central European background to be chronically infected with C. pneumoniae based on the repeated detection of chlamydial DNA in PBMC. Among those the - 159C> T CD14 promoter polymorphism was more frequent (OR 1.7, 95% CI 1.08-2.65, P = 0.0224) than among C. pneumoniae-negative subjects matched for age and gender. The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydial infection. Susceptibility for chronic chlamydial infection of PBMC in CAD patients appears associated with the CD14-159C> T promoter polymorphism encoding for enhanced CD14 expression.

AB - Chlamydia pneumoniae uses peripheral blood monocytes (PBMC) for systemic dissemination and has been linked to atherogenesis by inflammation mediated via TLR2/4 and CD14. We found 12.8% of 610 coronary artery disease (CAD) patients of Central European background to be chronically infected with C. pneumoniae based on the repeated detection of chlamydial DNA in PBMC. Among those the - 159C> T CD14 promoter polymorphism was more frequent (OR 1.7, 95% CI 1.08-2.65, P = 0.0224) than among C. pneumoniae-negative subjects matched for age and gender. The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydial infection. Susceptibility for chronic chlamydial infection of PBMC in CAD patients appears associated with the CD14-159C> T promoter polymorphism encoding for enhanced CD14 expression.

UR - https://www.scopus.com/pages/publications/4344675670

U2 - 10.1038/sj.gene.6364112

DO - 10.1038/sj.gene.6364112

M3 - Journal articles

C2 - 15175649

AN - SCOPUS:4344675670

SN - 1466-4879

VL - 5

SP - 435

EP - 438

JO - Genes and Immunity

JF - Genes and Immunity

IS - 5

ER -

CD14 promoter polymorphism - 159C> T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes

Abstract

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