Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro

J. Großkreutz; S. Quasthoff; M. Kühn; P. Grafe

doi:10.1016/0304-3940(96)12536-2

Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro

J. Großkreutz, S. Quasthoff^*, M. Kühn, P. Grafe

^*Korrespondierende/r Autor/-in für diese Arbeit

43 Zitate (Scopus)

Abstract

Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were explored on compound action potentials of isolated fascicles from human sural nerve biopsies. Capsaicin reduced the C fibre component by 30-60%; the remaining C fibres were not sensitive to the drug. A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin. Calcium action potentials seen after inhibition of axonal potassium conductances were also completely suppressed. The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.

Originalsprache	Englisch
Zeitschrift	Neuroscience Letters
Jahrgang	208
Ausgabenummer	1
Seiten (von - bis)	49-52
Seitenumfang	4
ISSN	0304-3940
DOIs	https://doi.org/10.1016/0304-3940(96)12536-2
Publikationsstatus	Veröffentlicht - 12.04.1996
Extern publiziert	Ja

Fördermittel

This work was supported by grants given by the Wilhelm Sander Stiftung (J.G., S.Q., M.K.) and the Deutsche Forschungsgemeinschaft (SFB 220/TP B 1, P.G.).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Zentren: Neuromuskuläres Zentrum Schleswig-Holstein

Dokumente

10.1016/0304-3940(96)12536-2

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title = "Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro",

abstract = "Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were explored on compound action potentials of isolated fascicles from human sural nerve biopsies. Capsaicin reduced the C fibre component by 30-60\%; the remaining C fibres were not sensitive to the drug. A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin. Calcium action potentials seen after inhibition of axonal potassium conductances were also completely suppressed. The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.",

author = "J. Gro{\ss}kreutz and S. Quasthoff and M. K{\"u}hn and P. Grafe",

note = "Funding Information: This work was supported by grants given by the Wilhelm Sander Stiftung (J.G., S.Q., M.K.) and the Deutsche Forschungsgemeinschaft (SFB 220/TP B 1, P.G.).",

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T1 - Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro

AU - Großkreutz, J.

AU - Quasthoff, S.

AU - Kühn, M.

AU - Grafe, P.

N1 - Funding Information: This work was supported by grants given by the Wilhelm Sander Stiftung (J.G., S.Q., M.K.) and the Deutsche Forschungsgemeinschaft (SFB 220/TP B 1, P.G.).

PY - 1996/4/12

Y1 - 1996/4/12

N2 - Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were explored on compound action potentials of isolated fascicles from human sural nerve biopsies. Capsaicin reduced the C fibre component by 30-60%; the remaining C fibres were not sensitive to the drug. A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin. Calcium action potentials seen after inhibition of axonal potassium conductances were also completely suppressed. The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.

AB - Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were explored on compound action potentials of isolated fascicles from human sural nerve biopsies. Capsaicin reduced the C fibre component by 30-60%; the remaining C fibres were not sensitive to the drug. A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin. Calcium action potentials seen after inhibition of axonal potassium conductances were also completely suppressed. The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.

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