Cancer immunology and HPV

Barbara Wollenberg*

*Korrespondierende/r Autor/-in für diese Arbeit
4 Zitate (Scopus)

Abstract

HNSCC is a heterogeneous group of tumors located in the oral cavity, oropharynx, hypopharynx and larynx. Originally, tobacco and alcohol exposures were the main risk factors for HNSCC. In the last two decades, HPV infections have been identified as a risk factor for HNSCC, especially for oropharyngeal tumors. Whereas the HPV-induced oropharyngeal carcinomas predominantly express the HPV16 related E6 and E7 oncoproteins, the HPV-negative HNSCC are associated with an overexpression of p53. However, if the therapy successes for HPV-negative and HPV-positive HNSCCs are compared, there are significantly higher total survival rates for HPV-positive oropharyngeal tumors compared to HPV-negative tumors. It is important to understand this phenomenon in order to improve and adapt therapy concepts.

OriginalspracheEnglisch
TitelRecent Results in Cancer Research
Seitenumfang6
Herausgeber (Verlag)Springer New York LLC
Erscheinungsdatum01.10.2017
Seiten243-248
ISBN (Print)978-3-319-43578-7
ISBN (elektronisch)978-3-319-43580-0
DOIs
PublikationsstatusVeröffentlicht - 01.10.2017

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