Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

Christof Burgdorf; Andreas Dendorfer; Thomas Kurz; Gert Richardt

doi:10.1016/j.regpep.2004.08.002

Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

Christof Burgdorf, Andreas Dendorfer, Thomas Kurz, Gert Richardt

Abstract

The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l ^-1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.

Originalsprache	Englisch
Zeitschrift	Regulatory Peptides
Jahrgang	125
Ausgabenummer	1-3
Seiten (von - bis)	99-102
Seitenumfang	4
ISSN	0167-0115
DOIs	https://doi.org/10.1016/j.regpep.2004.08.002
Publikationsstatus	Veröffentlicht - 15.02.2005

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.regpep.2004.08.002

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title = "Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia",

abstract = "The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.",

author = "Christof Burgdorf and Andreas Dendorfer and Thomas Kurz and Gert Richardt",

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T1 - Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

AU - Burgdorf, Christof

AU - Dendorfer, Andreas

AU - Kurz, Thomas

AU - Richardt, Gert

PY - 2005/2/15

Y1 - 2005/2/15

N2 - The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.

AB - The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.

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DO - 10.1016/j.regpep.2004.08.002

M3 - Journal articles

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AN - SCOPUS:9944242205

SN - 0167-0115

VL - 125

SP - 99

EP - 102

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 1-3

ER -

Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

Abstract

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