Abstract
Background: Infection with Helicobacter pylori strains may result in different pathological manifestations and increased oxidative stress leading to a strong inflammatory response in gastric mucosa. Aims: The prevalence of cagA and vacA genes, proteins and the association of serum levels of 8-hydroxy-2-deox-yguanosine (8-OHdG) with oxidative DNA damage were determined. Methods: The presence of cagA gene and vacA alleles and IgG antibodies against CagA and VacA proteins were determined. Oxidative DNA damage status was determined using serum levels of 8-OHdG. Results: Helicobacter pylori-positive, cagA-positive, and vacA alleles (s1 and m2) were predominant in all clinical outcomes. There was no significant association between prevalence of CagA and VacA status and clinical outcomes. The serum levels of 8-OHdG was at a higher level in H. pylori-positive patients. Conclusions: These virulence factors are not associated with the development of PUD in Iranian patients. H. pylori infection may be associated with increased serum 8-OHdG.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Irish Journal of Medical Science |
| Jahrgang | 180 |
| Ausgabenummer | 1 |
| Seiten (von - bis) | 155-161 |
| Seitenumfang | 7 |
| ISSN | 0021-1265 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 03.2011 |
Fördermittel
Acknowledgments This work was funded by Shahid Beheshti University of Medical Sciences and Health Services. Our gratitude also goes to Shahid Modarress Hospital staff for helpful collaboration. We would also like to thank Dr. Eznollah Azargashb for conduct of the statistical analyses.
UN SDGs
Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung
