Bullöse Autoimmunkrankheiten bei Kindern

M. Sárdy*, M. Kasperkiewicz

*Korrespondierende/r Autor/-in für diese Arbeit
4 Zitate (Scopus)

Abstract

We review the pathogenesis, clinical features, diagnosis, differential diagnosis, and therapy of autoimmune bullous skin diseases of childhood, especially of the most common linear IgA dermatosis. In autoimmune bullous diseases, autoantibodies are formed against different adhesion molecules of the skin. These are not only pathophysiologically relevant, but also serve as basis for diagnosis and follow-up of these diseases. In case an autoimmune bullous disease is suspected, histopathology and immunohistopathology (direct immunofluorescence microscopy) as well as serological tests (indirect immunofluorescence microscopy, ELISA, immunoblot) should be performed. Therapy depends on the diagnosis. In IgA-mediated pathogenesis, dapsone can be successfully used. In IgG-mediated diseases, immunosuppression with corticosteroids and steroid-sparing agents should be initiated, although only local therapy is sufficient to control a self-limiting pemphigus neonatorum. In dermatitis herpetiformis, a life-long gluten-free diet is recommended.
Titel in ÜbersetzungBullous autoimmune disorders in children
OriginalspracheDeutsch
ZeitschriftHautarzt
Jahrgang64
Ausgabenummer6
Seiten (von - bis)447-457
Seitenumfang11
ISSN0017-8470
DOIs
PublikationsstatusVeröffentlicht - 01.06.2013

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