Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

D. E. Dietrich; Y. Zhang; L. Bode; T. F. Münte; U. Hauser; P. Schmorl; C. Richter-Witte; T. Gödecke-Koch; S. Feutl; J. Schramm; H. Ludwig; S. Johannes; H. M. Emrich

doi:10.1038/sj.mp.4001688

Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

D. E. Dietrich^*, Y. Zhang, L. Bode, T. F. Münte, U. Hauser, P. Schmorl, C. Richter-Witte, T. Gödecke-Koch, S. Feutl, J. Schramm, H. Ludwig, S. Johannes, H. M. Emrich

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Neurologie

7 Zitate (Scopus)

Abstract

Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe ́) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

Originalsprache	Englisch
Zeitschrift	Molecular Psychiatry
Jahrgang	10
Ausgabenummer	6
Seitenumfang	1
ISSN	1359-4184
DOIs	https://doi.org/10.1038/sj.mp.4001688
Publikationsstatus	Veröffentlicht - 01.06.2005

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1038/sj.mp.4001688

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Dietrich, D. E., Zhang, Y., Bode, L., Münte, T. F., Hauser, U., Schmorl, P., Richter-Witte, C., Gödecke-Koch, T., Feutl, S., Schramm, J., Ludwig, H., Johannes, S., & Emrich, H. M. (2005). Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder. Molecular Psychiatry, 10(6). https://doi.org/10.1038/sj.mp.4001688

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title = "Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder",

abstract = "Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe{\' }) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.",

author = "Dietrich, {D. E.} and Y. Zhang and L. Bode and M{\"u}nte, {T. F.} and U. Hauser and P. Schmorl and C. Richter-Witte and T. G{\"o}decke-Koch and S. Feutl and J. Schramm and H. Ludwig and S. Johannes and Emrich, {H. M.}",

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Dietrich, DE, Zhang, Y, Bode, L, Münte, TF, Hauser, U, Schmorl, P, Richter-Witte, C, Gödecke-Koch, T, Feutl, S, Schramm, J, Ludwig, H, Johannes, S & Emrich, HM 2005, 'Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder', Molecular Psychiatry, Jg. 10, Nr. 6. https://doi.org/10.1038/sj.mp.4001688

TY - JOUR

T1 - Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

AU - Dietrich, D. E.

AU - Zhang, Y.

AU - Bode, L.

AU - Münte, T. F.

AU - Hauser, U.

AU - Schmorl, P.

AU - Richter-Witte, C.

AU - Gödecke-Koch, T.

AU - Feutl, S.

AU - Schramm, J.

AU - Ludwig, H.

AU - Johannes, S.

AU - Emrich, H. M.

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe ́) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

AB - Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe ́) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

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JO - Molecular Psychiatry

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Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

Abstract

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