BIT-ART: Multicentric comparison of HDR-brachytherapy, intensity-modulated radiotherapy and tomotherapy for advanced radiotherapy in prostate cancer

Anna Rita Alitto, Luca Tagliaferri, Valentina Lancellotta*, Andrea D’Aviero, Antonio Piras, Vincenzo Frascino, Francesco Catucci, Bruno Fionda, Christian Staackmann, Simonetta Saldi, Vincenzo Valentini, Gyorgy Kovacs, Cynthia Aristei, Giovanna Mantini

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Background/Aim: The aim of the study was to evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity in patients with high- or intermediate-risk prostate cancer. Patients and Methods: We evaluated data of patients from three Radiation Oncology Departments (Rome, Lübeck and Perugia). Patients treated in Rome underwent exclusive intensity-modulated-radiotherapy (IMRT) or IMRT plus high-dose-rate interventional radiotherapy (HDR-IRT). IMRT plus two fractions HDR-IRT was performed in Lübeck, while in Perugia Helical Tomotherapy was performed. The Common Toxicity Criteria for Adverse Event (Version 4.03) scale was used to describe acute and late toxicity. Results: At a median follow-up of 28 months, all 51 patients were alive and disease-free. Patients treated by HDR-IRT plus VMAT showed only G1-2 genitourinary- gastrointestinal (GU-GI) acute and late toxicity. Univariate analysis showed a lower risk of acute GU toxicity (p=0.048) in IMRT+HDR-IRT. Conclusion: Low grade and less acute GU toxicity was observed in patients undergoing HDR-IRT boost.

OriginalspracheEnglisch
ZeitschriftIn Vivo
Jahrgang34
Ausgabenummer3
Seiten (von - bis)1297-1305
Seitenumfang9
ISSN0258-851X
DOIs
PublikationsstatusVeröffentlicht - 06.2020

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