TY - JOUR
T1 - Biological Properties of Superparamagnetic Iron Oxide Nanoparticles
AU - Lindemann, Antje
AU - Pries, Ralph
AU - Lüdtke-Buzug, Kerstin
AU - Wollenberg, Barbara
N1 - Publisher Copyright:
© 1965-2012 IEEE.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Despite the intense progress achieved in processing the magnetic particle imaging (MPI) technology, there is no suitable tracer that satisfies all MPI requirements. For this purpose, dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) were designed and synthesized as appropriate MPI tracer. To ensure a prospective biosafe application of these nanoparticles, we started to evaluate the biocompatibility, including cell toxicity and cellular uptake. The SPIONs internalized into mouse fibroblast cells were showing good labeling efficiencies and a cytosolic accumulation. Flow cytometry analysis demonstrated no difference of the cell viability of labeled cells in comparison with unlabeled control cells. But we observed decreased cell proliferation in response to increased SPION concentrations. In conclusion, SPIONs could reveal harmful properties and, therefore, further experiments should be considered.
AB - Despite the intense progress achieved in processing the magnetic particle imaging (MPI) technology, there is no suitable tracer that satisfies all MPI requirements. For this purpose, dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) were designed and synthesized as appropriate MPI tracer. To ensure a prospective biosafe application of these nanoparticles, we started to evaluate the biocompatibility, including cell toxicity and cellular uptake. The SPIONs internalized into mouse fibroblast cells were showing good labeling efficiencies and a cytosolic accumulation. Flow cytometry analysis demonstrated no difference of the cell viability of labeled cells in comparison with unlabeled control cells. But we observed decreased cell proliferation in response to increased SPION concentrations. In conclusion, SPIONs could reveal harmful properties and, therefore, further experiments should be considered.
UR - http://www.scopus.com/inward/record.url?scp=84930675674&partnerID=8YFLogxK
U2 - 10.1109/TMAG.2014.2358257
DO - 10.1109/TMAG.2014.2358257
M3 - Journal articles
AN - SCOPUS:84930675674
SN - 0018-9464
VL - 51
SP - 5200204
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
IS - 2
ER -