Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa; Ellen Kanitz; Winfried Otten; Saleh M. Ibrahim

doi:10.1111/j.1749-6632.2008.03960.x

Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa^*, Ellen Kanitz, Winfried Otten, Saleh M. Ibrahim

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Dermatologie, Allergologie und Venerologie

Leibniz-Institut für Nutztierbiologie

35 Zitate (Scopus)

Abstract

We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mt^FVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt ^AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

Originalsprache	Englisch
Titel	Neuroimmunomodulation: From Fundamental Biology to Therapy
Seitenumfang	8
Herausgeber (Verlag)	Blackwell Publishing Inc.
Erscheinungsdatum	02.2009
Seiten	131-138
ISBN (Print)	9781573317467
DOIs	https://doi.org/10.1111/j.1749-6632.2008.03960.x
Publikationsstatus	Veröffentlicht - 02.2009

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title = "Behavior and stress reactivity in mouse strains with mitochondrial DNA variations",

abstract = "We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.",

author = "Ulrike Gimsa and Ellen Kanitz and Winfried Otten and Ibrahim, \{Saleh M.\}",

year = "2009",

month = feb,

doi = "10.1111/j.1749-6632.2008.03960.x",

language = "English",

isbn = "9781573317467",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing Inc.",

pages = "131--138",

booktitle = "Neuroimmunomodulation: From Fundamental Biology to Therapy",

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Behavior and stress reactivity in mouse strains with mitochondrial DNA variations. / Gimsa, Ulrike; Kanitz, Ellen; Otten, Winfried et al.
Neuroimmunomodulation: From Fundamental Biology to Therapy. Blackwell Publishing Inc., 2009. S. 131-138 (Annals of the New York Academy of Sciences; Band 1153).

Publikation: Kapitel in Büchern/Berichten/Konferenzbänden › Konferenzbeitrag › Begutachtung

TY - GEN

T1 - Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

AU - Gimsa, Ulrike

AU - Kanitz, Ellen

AU - Otten, Winfried

AU - Ibrahim, Saleh M.

PY - 2009/2

Y1 - 2009/2

N2 - We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

AB - We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

UR - https://www.scopus.com/pages/publications/60349089146

U2 - 10.1111/j.1749-6632.2008.03960.x

DO - 10.1111/j.1749-6632.2008.03960.x

M3 - Conference contribution

C2 - 19236336

AN - SCOPUS:60349089146

SN - 9781573317467

T3 - Annals of the New York Academy of Sciences

SP - 131

EP - 138

BT - Neuroimmunomodulation: From Fundamental Biology to Therapy

PB - Blackwell Publishing Inc.

ER -

Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Abstract

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